CAJ | 학술논문

目的：探讨分析川芎嗪联合醒脑静治疗急性脑梗死的疗效及对神经功能缺损和血液流变学的影响。方法选取急性脑梗死患者102例，按数字表格法随机分为两组，每组51例。对照组在基础综合治疗的基础上给予血栓通冻干粉，观察组则给予川芎嗪联合醒脑静，14 d为1个疗程。观察分析两组患者的临床疗效及神经功能缺损程度评分（ NIHSS）和血流动力学的改变。结果观察组治疗后总有效率为96.08%，显著高于对照组的78.43%（ P﹤0.05）；治疗后两组患者的血液流变学指标及神经功能缺损均较治疗前明显改善（ P ﹤0.05），观察组较对照组改善更显著（ P ﹤0.05）。结论川芎嗪联合醒脑静治疗急性脑梗死可显著提高疗效，有效改善患者的神经功能及血液流变学指标，降低血黏稠度，增加脑血流量，明显改善预后。
목적：탐토분석천궁진연합성뇌정치료급성뇌경사적료효급대신경공능결손화혈액류변학적영향。방법선취급성뇌경사환자102례，안수자표격법수궤분위량조，매조51례。대조조재기출종합치료적기출상급여혈전통동간분，관찰조칙급여천궁진연합성뇌정，14 d위1개료정。관찰분석량조환자적림상료효급신경공능결손정도평분（ NIHSS）화혈류동역학적개변。결과관찰조치료후총유효솔위96.08%，현저고우대조조적78.43%（ P﹤0.05）；치료후량조환자적혈액류변학지표급신경공능결손균교치료전명현개선（ P ﹤0.05），관찰조교대조조개선경현저（ P ﹤0.05）。결론천궁진연합성뇌정치료급성뇌경사가현저제고료효，유효개선환자적신경공능급혈액류변학지표，강저혈점주도，증가뇌혈류량，명현개선예후。
Objective To investigate the effect of Ligustrazine combined with Xingnaojing Injection in treatment of acute cerebral infarc-tion and its effect on the nervous function defect and blood rheology. Methods 102 cases of patients with acute cerebral infarction were selected into this study. All patients were treated in department of internal medicine of our hospital patients,and were randomly divided into 2 groups of 51 cases according to the number table method. The control group was given Xueshuantong lyophilized powder based on the basis of comprehensive therapy while the observation group was treated with Ligustrazine combined with Xingnaojing injection,14 d for 1 course. Clinical efficacy,neuro-logical deficit score and change of hemorheology indexes of two groups of patients were observed and compared. Results The total effective rate of the observation group was 96. 08%,significantly higher than 78. 43%that in control group( P ﹤0. 05). The blood rheology indexes of the two groups after treatment were significantly lower than those before treatment( P ﹤0. 05). Each index of the observation group was lower than that of the control group( P ﹤0. 05). The neurological function of two groups of patients was obviously improved. The observation group was better than control group( P ﹤0. 05). Conclusion Ligustrazine combined with Xingnaojing Injection can significantly improve the curative effect in the treatment of acute cerebral infarction and improve nerve function and hemorheology index,decrease blood viscosity,increase cerebral blood flow, and significantly improve prognosis.