CAJ | 학술논문

目的：探讨颅内静脉窦血栓（ CVST）急性期的临床特点及治疗策略的选择。方法回顾性分析26例急性期CVST患者的临床资料，住院期间分别接受全身抗凝、静脉溶栓和血管内治疗，并辅助华法林口服6~12个月。结果26例急性期CVST患者中16例患者接受单纯全身抗凝药物治疗，6例接受单纯静脉溶栓，4例接受全身抗凝+血管内溶栓治疗（其中2例因抗凝治疗过程中，病情加重，转为血管内溶栓治疗）。出院时，所有患者闭塞静脉窦均再通或部分再通，临床症状改善。随访6~26月，平均18月，无一例血栓再形成。结论急性期CVST应根据病情程度选择个性化治疗方案，其影响因素为临床表现、闭塞程度及侧支循环开放程度。
목적：탐토로내정맥두혈전（ CVST）급성기적림상특점급치료책략적선택。방법회고성분석26례급성기CVST환자적림상자료，주원기간분별접수전신항응、정맥용전화혈관내치료，병보조화법림구복6~12개월。결과26례급성기CVST환자중16례환자접수단순전신항응약물치료，6례접수단순정맥용전，4례접수전신항응+혈관내용전치료（기중2례인항응치료과정중，병정가중，전위혈관내용전치료）。출원시，소유환자폐새정맥두균재통혹부분재통，림상증상개선。수방6~26월，평균18월，무일례혈전재형성。결론급성기CVST응근거병정정도선택개성화치료방안，기영향인소위림상표현、폐새정도급측지순배개방정도。
Objective The aim of this study is to discuss the clinical characteristic and the selection of treatment of acute cerebral vein si-nus thrombosis. Methods Clinical data of 26 patients diagnosed with acute CVST were retrospectively analyzed. These patients were treated with simple anticoagulant therapy,intravenous thrombolytic therapy,and endovascular thrombolysis. Then all the patients took oral warfarin for 6~12 months. Results Among 16 patients who received systemic anticoagulant therapy,13 were cured,3 were improved. Among 6 patients who accept-ed intravenous thrombolytic therapy,4 were cured,2 were improved. Among 4 patients who accepted endovascular thrombolysis,3 were cured,1 was improved. The period of follow-up was between 6 months and 26 months( the median time was 18 months),and no recurrence happened or reported. Conclusion Personalized treatment of acute CVST should be selected in clinical practice. The influencing factors included the clinical manifestations,the degree of occlusion of cerebral vein sinus,and collateral circulation.