CAJ | 학술논문

目的：研究在食管癌同步放化疗中应用大剂量的甲羟孕酮的临床效果。方法将2007年6月至2013年6月收治的中晚期食管癌患者80例，按照随机数字表法分为试验组和对照组，每组各40例。试验组给予放化疗的同时应用甲羟孕酮，250 mg每日一次；对照组单用同期放化疗治疗的方案。观察两组治疗的临床效果和不良反应。结果试验组的有效率（97.5%）明显的高于对照组（87.5%），差异具有统计学意义（ P ﹤0.05）；食欲与疼痛的变化方面试验组改善效果优于对照组，差异具有统计学意义（ P ﹤0.05）。治疗后两组体重，血浆白蛋白之间的差异变化明显，试验组改善优于对照组（ P ﹤0.05）。不良反应如白细胞下降Ⅱ度以上、血红蛋白下降Ⅱ度以上、胃肠道反应Ⅱ度以上所占患者比率试验组均显著低于对照组，差异具有统计学意义（ P ﹤0.05）。结论食管癌同步放化疗中应用大剂量的甲羟孕酮不仅可以明显提高治疗的效果，同时也可以减少或者改善不良反应事件的发生。
목적：연구재식관암동보방화료중응용대제량적갑간잉동적림상효과。방법장2007년6월지2013년6월수치적중만기식관암환자80례，안조수궤수자표법분위시험조화대조조，매조각40례。시험조급여방화료적동시응용갑간잉동，250 mg매일일차；대조조단용동기방화료치료적방안。관찰량조치료적림상효과화불량반응。결과시험조적유효솔（97.5%）명현적고우대조조（87.5%），차이구유통계학의의（ P ﹤0.05）；식욕여동통적변화방면시험조개선효과우우대조조，차이구유통계학의의（ P ﹤0.05）。치료후량조체중，혈장백단백지간적차이변화명현，시험조개선우우대조조（ P ﹤0.05）。불량반응여백세포하강Ⅱ도이상、혈홍단백하강Ⅱ도이상、위장도반응Ⅱ도이상소점환자비솔시험조균현저저우대조조，차이구유통계학의의（ P ﹤0.05）。결론식관암동보방화료중응용대제량적갑간잉동불부가이명현제고치료적효과，동시야가이감소혹자개선불량반응사건적발생。
Objective To study the application of esophageal chemoradiation in large doses of medroxyprogesterone clinical effect. Meth-ods In our hospital oncology in June 2007 to June 2013 patients,80 cases of the patients,according to random number table method was divided into experimental group and the control group,40 cases in each group. Patients in experimental group received radiation and chemotherapy and medroxyprogesterone,250 mg once daily. Patients in the control group received radiation and chemotherapy treatment scheme at the same time. The effect of two groups of treatment including side effect was observed. Results The effective rate in the two groups of experimental was 97. 5%in experimental group,87. 5% in the control group,which is lower than that of experimental group. There was statistically significant difference( P ﹤0. 05). Changes in appetite and pain between the two groups have statistical significance( P ﹤0. 05). The difference between plasma albu-min changes significantly. And the difference between the two groups have statistical significance( P ﹤0. 05). Statistically significant difference was demonstrated compared with before treatment( P ﹤0. 05). Adverse reactions such as leukopenia Ⅱ degrees,hemoglobin decreased Ⅱ de-grees,gastrointestinal reactions in patients with gradeⅡshare ratio over the test group were significantly lower than that of the control group,the difference was statistically significant( P ﹤0. 05). Conclusion Duct carcinoma chemoradiation application of large doses of medroxyprogester-one not only can improve the effects of the treatment and at the same time can also reduce or improve the occurrence of adverse reactions of time.