CAJ | 학술논문

目的：观察左归丸加减联合柳氮磺吡啶片治疗强直性脊柱炎（AS）的临床疗效。方法：采用随机数字表法将91例确诊AS患者进行分组，对照组45例给予口服柳氮磺吡啶片治疗，观察组46例加用左归丸加减治疗，连续治疗8周末对比临床疗效。结果：观察组治疗后总有效率93.48%明显高于对照组77.78%，P＜0.05；两组均能够降低脊柱功能指标，改善脊柱功能，但观察组降低脊柱功能指标幅度明显高于对照组，P＜0.01；观察组不良反应发生率8.70%与对照组6.67%比较，P﹥0.05。结论：左归丸加减联合柳氮磺吡啶片治疗AS效果确切，能够运用现代医学结合传统医学改善临床症状与体征，安全可靠，值得临床对作用机制继续研究和探讨。
목적：관찰좌귀환가감연합류담광필정편치료강직성척주염（AS）적림상료효。방법：채용수궤수자표법장91례학진AS환자진행분조，대조조45례급여구복류담광필정편치료，관찰조46례가용좌귀환가감치료，련속치료8주말대비림상료효。결과：관찰조치료후총유효솔93.48%명현고우대조조77.78%，P＜0.05；량조균능구강저척주공능지표，개선척주공능，단관찰조강저척주공능지표폭도명현고우대조조，P＜0.01；관찰조불량반응발생솔8.70%여대조조6.67%비교，P﹥0.05。결론：좌귀환가감연합류담광필정편치료AS효과학절，능구운용현대의학결합전통의학개선림상증상여체정，안전가고，치득림상대작용궤제계속연구화탐토。
Objective:To observe the clinical curative efficacyof left-returing Pill combined with sulfasalazine tablets on the treatment of ankylosing spondylitis (AS). Methods: 91 cases with AS were divided into two groups by random number table. 45 patients in the control group of were treated with oral administration of sulfasalazine tablet. The other 46 cases in the observation group were treated with left-returning Pill. 8 weeks after the treatment, the clinical efficacy of the two groups were compared. Results:The total effective rate of the observation group was 93.48%which was significantly higher than that (77.78%) of the control group, P<0.05;Both treatment of the two groups were able to reduce spinal function parameters and improve spinal function, but reduction of spinal function parameters of the observation group was significantly higher than that of the control group, P<0.01; The incidence rate of adverse reactions of the observation group was 8.70%and the control group 6.67%, P>0.05. Conclusion:Left-returning Pill combined with sulfasalazine tablet has definite effect on treating AS exact. The combination of traditional medicine and modern medicine can improve clinical symptoms and signs. It is safe and reliable. Its mechanism of action is worthy of further clinical study and discussion.