中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
32期
15-16
,共2页
肺表面活性物质%新生儿胎粪吸入综合征%肺氧合功能
肺錶麵活性物質%新生兒胎糞吸入綜閤徵%肺氧閤功能
폐표면활성물질%신생인태분흡입종합정%폐양합공능
Pulmonary surfactant%Meconium aspiration syndrome%Pulmonary oxygenation function
目的：研究探讨肺表面活性物质(PS)对新生儿胎粪吸入综合征(MAS)的肺氧合功能的影响。方法采用气管内滴入PS治疗10例MAS患儿,对用药前、用药后30 min、2 h及6 h血气指标,机械通气参数进行比较分析,判断肺氧合情况。结果10例患儿血气指标及机械通气的参数用药前与用药30 min后比较差异有统计学意义(P<0.05),动脉血氧分压(PaO2)由(42.81±4.68)mm Hg(1 mm Hg=0.133 kPa)升高至(55.19±4.82)mm Hg,动脉与肺泡氧分压比值(a/APO2)由(0.11±0.06)升高至(0.20±0.05),动脉血氧分压与吸入氧浓度比值(PaO2/FiO2)由(67.04±18.00)mm Hg升高至(97.13±24.14)mm Hg, FiO2由(0.66±0.10)降至(0.54±0.08),平均气道压(MAP)由(15.52±3.15)cm H2O(1 cm H2O=0.098 kPa)降至(11.67±2.85)cm H2O。氧合指数(OI)由(22.16±2.12)降至(14.16±1.67),差异均具有统计学意义(P<0.05)。结论肺表面活性物质能有效地改善MAS患儿肺氧合功能。
目的：研究探討肺錶麵活性物質(PS)對新生兒胎糞吸入綜閤徵(MAS)的肺氧閤功能的影響。方法採用氣管內滴入PS治療10例MAS患兒,對用藥前、用藥後30 min、2 h及6 h血氣指標,機械通氣參數進行比較分析,判斷肺氧閤情況。結果10例患兒血氣指標及機械通氣的參數用藥前與用藥30 min後比較差異有統計學意義(P<0.05),動脈血氧分壓(PaO2)由(42.81±4.68)mm Hg(1 mm Hg=0.133 kPa)升高至(55.19±4.82)mm Hg,動脈與肺泡氧分壓比值(a/APO2)由(0.11±0.06)升高至(0.20±0.05),動脈血氧分壓與吸入氧濃度比值(PaO2/FiO2)由(67.04±18.00)mm Hg升高至(97.13±24.14)mm Hg, FiO2由(0.66±0.10)降至(0.54±0.08),平均氣道壓(MAP)由(15.52±3.15)cm H2O(1 cm H2O=0.098 kPa)降至(11.67±2.85)cm H2O。氧閤指數(OI)由(22.16±2.12)降至(14.16±1.67),差異均具有統計學意義(P<0.05)。結論肺錶麵活性物質能有效地改善MAS患兒肺氧閤功能。
목적：연구탐토폐표면활성물질(PS)대신생인태분흡입종합정(MAS)적폐양합공능적영향。방법채용기관내적입PS치료10례MAS환인,대용약전、용약후30 min、2 h급6 h혈기지표,궤계통기삼수진행비교분석,판단폐양합정황。결과10례환인혈기지표급궤계통기적삼수용약전여용약30 min후비교차이유통계학의의(P<0.05),동맥혈양분압(PaO2)유(42.81±4.68)mm Hg(1 mm Hg=0.133 kPa)승고지(55.19±4.82)mm Hg,동맥여폐포양분압비치(a/APO2)유(0.11±0.06)승고지(0.20±0.05),동맥혈양분압여흡입양농도비치(PaO2/FiO2)유(67.04±18.00)mm Hg승고지(97.13±24.14)mm Hg, FiO2유(0.66±0.10)강지(0.54±0.08),평균기도압(MAP)유(15.52±3.15)cm H2O(1 cm H2O=0.098 kPa)강지(11.67±2.85)cm H2O。양합지수(OI)유(22.16±2.12)강지(14.16±1.67),차이균구유통계학의의(P<0.05)。결론폐표면활성물질능유효지개선MAS환인폐양합공능。
Objective To explore the influence of pulmonary surfactant (PS) on pulmonary oxygenation function of meconium aspiration syndrome (MAS). Methods A total of 10 infants with MAS were treated by PS through intratracheal instillation. Comparisons were made on the blood gas, mechanical ventilation parameters, and ratio of arterial partial pressure of oxygen and oxygen concentration before and in 30 min, 2 h and 6 h after treatment medication, in order to analyze the condition of pulmonary oxygenation. Results The difference of blood gas and mechanical ventilation parameters in the 10 infants between the time before medication and 30 min after medication was statistically significant (P<0.05). Arterial partial pressure of oxygen (PaO2) increased from (42.81±4.68) mm Hg (1 mm Hg=0.133 kPa) to (55.19±4.82) mm Hg. Ratio of artery and alveolar partial pressure of oxygen (a/PaO2) increased from (0.11±0.06) to (0.20±0.05). Ratio of arterial partial pressure of oxygen and oxygen concentration (PaO2/FiO2) increased from (67.04±18.00) mm Hg to (97.13±24.14) mm Hg. FiO2 decreased from (0.66±0.10) to (0.54±0.08). Mean arterial pressure (MAP) decreased from (15.52±3.15) cm H2O (1 cm H2O=0.098 kPa) to (11.67±2.85) cm H2O. Oxygenation index (OI) decreased from (22.16±2.12) to (14.16±1.67). The differences had statistical significance (P<0.05). Conclusion PS can efficiently improve the pulmonary oxygenation function of MAS infants.
