CAJ | 학술논문

目的：探讨经过干预的甲状腺功能减退症对自然流产的影响。方法对30只患有甲状腺功能减退症的大鼠进行左甲状腺素干预，合笼后观察其妊娠结局。用酶联免疫吸附实验（ELISA法）测定大鼠血清中游离甲状腺素（FT4）、促甲状腺激素（TSH）、甲状腺过氧化物酶抗体（TPO-Ab）水平，进行阴道涂片，观察其动情周期，合笼后观察其妊娠结局。结果甲减组与甲减治疗组相比FT4水平较低，TSH偏高，TPO-Ab偏高，均有显著性差异（P<0.05）；甲减治疗组与正常对照组相比三种激素水平无显著性差异（P>0.05）；甲减治疗组与正常对照组仔鼠数量相比无显著性差异（P>0.05）。结论甲状腺功能减退症是导致自然流产的因素之一，可通过左甲状腺素治疗改善妊娠结局。
목적：탐토경과간예적갑상선공능감퇴증대자연유산적영향。방법대30지환유갑상선공능감퇴증적대서진행좌갑상선소간예，합롱후관찰기임신결국。용매련면역흡부실험（ELISA법）측정대서혈청중유리갑상선소（FT4）、촉갑상선격소（TSH）、갑상선과양화물매항체（TPO-Ab）수평，진행음도도편，관찰기동정주기，합롱후관찰기임신결국。결과갑감조여갑감치료조상비FT4수평교저，TSH편고，TPO-Ab편고，균유현저성차이（P<0.05）；갑감치료조여정상대조조상비삼충격소수평무현저성차이（P>0.05）；갑감치료조여정상대조조자서수량상비무현저성차이（P>0.05）。결론갑상선공능감퇴증시도치자연유산적인소지일，가통과좌갑상선소치료개선임신결국。
Objective To study the effect of hypothyroidism be treated with levothyroxine on spontaneous abortion. Method In 30 rats suffered from hypothyroidism treated with levothyroxine,observe their pregnancy outcomes. With Methods Enzyme-linked immunosorbent assay (ELISA) was adopted to measure rats serum FT4、TSH、TPO-Ab levels,doing the vaginal smears,finding their estrous cycle, observe their pregnancy outcomes. Giving the rats which suffered from hypothyroidism levothyroxine therapy, observe their pregnancy outcomes,and with Methods ELISA was adopted to measure rats serum FT4、TSH、TPO-Ab levels. Results To compare the hypothyroidism abortion group and the hypothyroidism abortion be treated group,FT4 levels are lower,TSH levels are higher,TPO-Ab levels are higher, there were significant differences between two groups in these three assays (P<0.05);To compare the hypothyroidism abortion be treated group and the normal control group,there was no significant difference in these three assays(P>0. 05);To compare offspring numbers of the hypothyroidism abortion be treated group and the normal control group,there was no significant difference in these three assays (P>0.05).Conclusion Hypothyroidism is one of the factors causing spontaneous abortion,can improve the pregnancy outcomes by levothyroxine treatment.