临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
CHINESE JOURNAL OF CLINICAL RATIONAL DRUG USE
2014年
23期
6-7
,共2页
潘志兰%张永梅%张志敏%杨彦%冯丽倩%邢英杰
潘誌蘭%張永梅%張誌敏%楊彥%馮麗倩%邢英傑
반지란%장영매%장지민%양언%풍려천%형영걸
多发性骨髓瘤%肾损害%临床特点%危险因素
多髮性骨髓瘤%腎損害%臨床特點%危險因素
다발성골수류%신손해%림상특점%위험인소
Multiple myeloma%Kidney damage%Clinical characteristics%Risk factors
目的：观察多发性骨髓瘤（MM）的临床特点，研究 MM 肾病发生的相关因素。方法对医院收治的48例 MM 肾病患者的临床资料进行总结分析。结果48例患者，男27例，女21例，中位年龄为58岁，临床表现为不同程度的贫血、蛋白尿、溶骨性损害。骨髓液中浆细胞数与肾功能损害有明显相关性（ P ﹤0.01），贫血、高钙血症、高β2微球蛋白水平及高血尿酸与 MM 肾脏损害有相关关系。结论 MM 肾病的临床表现多样性，浆细胞数量、贫血、高钙血症、高β2微球蛋白水平及高尿酸可能与 MM 肾病发生有关。
目的：觀察多髮性骨髓瘤（MM）的臨床特點，研究 MM 腎病髮生的相關因素。方法對醫院收治的48例 MM 腎病患者的臨床資料進行總結分析。結果48例患者，男27例，女21例，中位年齡為58歲，臨床錶現為不同程度的貧血、蛋白尿、溶骨性損害。骨髓液中漿細胞數與腎功能損害有明顯相關性（ P ﹤0.01），貧血、高鈣血癥、高β2微毬蛋白水平及高血尿痠與 MM 腎髒損害有相關關繫。結論 MM 腎病的臨床錶現多樣性，漿細胞數量、貧血、高鈣血癥、高β2微毬蛋白水平及高尿痠可能與 MM 腎病髮生有關。
목적：관찰다발성골수류（MM）적림상특점，연구 MM 신병발생적상관인소。방법대의원수치적48례 MM 신병환자적림상자료진행총결분석。결과48례환자，남27례，녀21례，중위년령위58세，림상표현위불동정도적빈혈、단백뇨、용골성손해。골수액중장세포수여신공능손해유명현상관성（ P ﹤0.01），빈혈、고개혈증、고β2미구단백수평급고혈뇨산여 MM 신장손해유상관관계。결론 MM 신병적림상표현다양성，장세포수량、빈혈、고개혈증、고β2미구단백수평급고뇨산가능여 MM 신병발생유관。
Objective Research the clinical characteristics and the etiological factor of Multiple myeloma. Methods The clinical data of 48 cases of multiple myeloma nephropathy were analyzed retrospectively. Results In 48 patients,male 27 cases,female 21 cases,median age 58 years. The clinical manifestations are different degrees of anaemia,albuminuria and os-teolytic lesions. There was significant correlation between the number of plasma cells and renal function damage in bone mar-row. Multiple myeloma kidney damage was associated with Anemia,hypercalcemia,high β2-microglobulin level,high level of serum uric acid and high uric acid. Conclusion Clinical manifestations of Multiple myeloma kidney damage are varied,and it was associated with Anemia,hypercalcemia,high β2-microglobulin level,high level of serum uric acid and high uric acid.
