CAJ | 학술논문

目的：考察注射用庆大霉素与奥硝唑氯化钠注射液的配伍稳定性，为临床给药提供科学依据。方法用紫外分光光度法考察注射用庆大霉素与奥硝唑氯化钠注射在室温（25℃）条件下配伍的稳定性。结果注射用庆大霉素和奥硝唑氯化钠注射液配伍在常温下8h 内，配伍液外观及 pH 值无明显变化，配伍液的紫外吸收曲线、最大波长几乎无变化，含量变化﹤5%，可以配伍使用。4h 后 pH 值随时间推移略有降低。结论临床注射用庆大霉素和奥硝唑氯化钠注射液配伍时，不宜放置过久，最好应在4h 内用完。
목적：고찰주사용경대매소여오초서록화납주사액적배오은정성，위림상급약제공과학의거。방법용자외분광광도법고찰주사용경대매소여오초서록화납주사재실온（25℃）조건하배오적은정성。결과주사용경대매소화오초서록화납주사액배오재상온하8h 내，배오액외관급 pH 치무명현변화，배오액적자외흡수곡선、최대파장궤호무변화，함량변화﹤5%，가이배오사용。4h 후 pH 치수시간추이략유강저。결론림상주사용경대매소화오초서록화납주사액배오시，불의방치과구，최호응재4h 내용완。
Objective To evaluate the stability of gentamicin injection combined with ornidazole and sodium chloride injection,in order to provide a scientific basis for clinical administration. Methods The stability of gentamicin injection com-bined with ornidazole and sodium chloride injection was evaluated by UV spectrophotometry at room temperature(25℃ )con-ditions. Results In 8 hours,the appearance and pH value of mixed liquor including gentamicin and ornidazole and sodium chloride injection at room temperature had no significant changes,the UV absorption curve,the maximum wavelength was al-most no change,small changes in content was 5% ,which could be mixed. After 4 hours,the pH value decreased slightly over time. Conclusion The compatibility solution of gentamicin injection and sodium chloride injection preferably should be used within 4h,not too long.