基层医学论坛
基層醫學論罈
기층의학론단
PUBLIC MEDICAL FORUM MAGAZINE
2014年
25期
3328-3330
,共3页
血小板计数增多%慢性粒细胞白血病%融合基因%染色体
血小闆計數增多%慢性粒細胞白血病%融閤基因%染色體
혈소판계수증다%만성립세포백혈병%융합기인%염색체
Thrombocytosis%Chronic myeloid leukemia%Fusion gene%Chromosome
目的:研究以血小板计数增多发病的慢性粒细胞白血病的临床表现与生物学特点。方法对患者外周血细胞形态、骨髓细胞形态、染色体、融合基因进行检查。结果以血小板计数增多发病的慢性粒细胞白血病的临床发病率低,易误诊为原发性血小板增多症,可检测到bcr/abl融合基因及Ph染色体,随病程进展,可进一步向加速期、急变期演变,应及早干预。结论对于以血小板计数增多发病的患者,应注意检测bcr/abl融合基因及Ph染色体,鉴别慢性粒细胞白血病与原发性血小板增多症,以避免误诊、误治。
目的:研究以血小闆計數增多髮病的慢性粒細胞白血病的臨床錶現與生物學特點。方法對患者外週血細胞形態、骨髓細胞形態、染色體、融閤基因進行檢查。結果以血小闆計數增多髮病的慢性粒細胞白血病的臨床髮病率低,易誤診為原髮性血小闆增多癥,可檢測到bcr/abl融閤基因及Ph染色體,隨病程進展,可進一步嚮加速期、急變期縯變,應及早榦預。結論對于以血小闆計數增多髮病的患者,應註意檢測bcr/abl融閤基因及Ph染色體,鑒彆慢性粒細胞白血病與原髮性血小闆增多癥,以避免誤診、誤治。
목적:연구이혈소판계수증다발병적만성립세포백혈병적림상표현여생물학특점。방법대환자외주혈세포형태、골수세포형태、염색체、융합기인진행검사。결과이혈소판계수증다발병적만성립세포백혈병적림상발병솔저,역오진위원발성혈소판증다증,가검측도bcr/abl융합기인급Ph염색체,수병정진전,가진일보향가속기、급변기연변,응급조간예。결론대우이혈소판계수증다발병적환자,응주의검측bcr/abl융합기인급Ph염색체,감별만성립세포백혈병여원발성혈소판증다증,이피면오진、오치。
Objective To study the clinical and biological characteristics of chronic myeloid leukemia(CML) with thrombocytosis.Methods The changes of patients were observed by blood films, bone marrow smear and biopsy. The bcr/abl fusion gene was examined by reverse transcription-polymerase chain reaction assay. The genetic changes of the cells were determined by conventional chromosome analysis. Result The patients of chronic myeloid leukemia with thrombocytosis were very rare and might be misdiagnosed as essential thrombocythemia. The bcr/abl fusion gene and the Ph chromosome were examined in the patints,and they could develop into accelerated phrase or blast crises of CML.So ealier intervetion is necessary. Conclusion CML with marked thrombocythemic onset has unique clinical and biological charactoristics. It is necessary to diffentiate ET and CML by examining the bcr/abl fusion gene and the Ph chromosome in order to avoid diagnosing and treating incorrectly.