微循环学杂志
微循環學雜誌
미순배학잡지
CHINESE JOURNAL OF MICROCIRCULATION
2014年
3期
32-34
,共3页
钙调蛋白%急性缺血性脑卒中
鈣調蛋白%急性缺血性腦卒中
개조단백%급성결혈성뇌졸중
Calmodulin%Acute ischemic stroke
目的：观察急性缺血性脑卒中(IS)后48h 血清钙调蛋白(CAM)水平变化及与美国国立卫生研究院卒中量表(NIHSS)评分的关系。方法：急性 IS患者(IS组,n=120),入院时采用 NIHSS进行评分,并按 NIHSS评分>5分(A组,n=51)和 NIHSS评分≤5分(B组,n=69)分为两个亚组,于 IS后48h测定血清 CAM值；另取体检健康人群(对照组,n=100)平行测定血清CAM值。比较 IS组与对照组以及不同 NIHSS评分 IS患者血清 CAM水平差异,分析 IS组CAM水平与 NIHSS评分的相关性。结果：IS组血清 CAM值较对照组显著增高(t=15.34,P<0.01)；A组患者CAM水平明显高于B组(t=10.51,P<0.01)；急性IS患者血清CAM水平与NIHSS评分呈显著正相关(r=0.308,P<0.01)。结论：血清CAM水平可反映 IS患者急性期病情程度。
目的：觀察急性缺血性腦卒中(IS)後48h 血清鈣調蛋白(CAM)水平變化及與美國國立衛生研究院卒中量錶(NIHSS)評分的關繫。方法：急性 IS患者(IS組,n=120),入院時採用 NIHSS進行評分,併按 NIHSS評分>5分(A組,n=51)和 NIHSS評分≤5分(B組,n=69)分為兩箇亞組,于 IS後48h測定血清 CAM值；另取體檢健康人群(對照組,n=100)平行測定血清CAM值。比較 IS組與對照組以及不同 NIHSS評分 IS患者血清 CAM水平差異,分析 IS組CAM水平與 NIHSS評分的相關性。結果：IS組血清 CAM值較對照組顯著增高(t=15.34,P<0.01)；A組患者CAM水平明顯高于B組(t=10.51,P<0.01)；急性IS患者血清CAM水平與NIHSS評分呈顯著正相關(r=0.308,P<0.01)。結論：血清CAM水平可反映 IS患者急性期病情程度。
목적：관찰급성결혈성뇌졸중(IS)후48h 혈청개조단백(CAM)수평변화급여미국국립위생연구원졸중량표(NIHSS)평분적관계。방법：급성 IS환자(IS조,n=120),입원시채용 NIHSS진행평분,병안 NIHSS평분>5분(A조,n=51)화 NIHSS평분≤5분(B조,n=69)분위량개아조,우 IS후48h측정혈청 CAM치；령취체검건강인군(대조조,n=100)평행측정혈청CAM치。비교 IS조여대조조이급불동 NIHSS평분 IS환자혈청 CAM수평차이,분석 IS조CAM수평여 NIHSS평분적상관성。결과：IS조혈청 CAM치교대조조현저증고(t=15.34,P<0.01)；A조환자CAM수평명현고우B조(t=10.51,P<0.01)；급성IS환자혈청CAM수평여NIHSS평분정현저정상관(r=0.308,P<0.01)。결론：혈청CAM수평가반영 IS환자급성기병정정도。
Objective:To observe the relationship between the change of the serum calmodulin(CAM)level at 48 hours af-ter acute ischemic stroke(IS)with the U.S national institutes of health stroke scale(NIHSS)score.Method:The a-cute IS patients(IS group,n=120),using NIHSS score at admission,according to NIHSS score> 5 (group A,n=51)and NIHSS score ≤ 5 (group B,n= 69)were divided into two subgroups.The serum CAM values at 48 hours after acute IS were measured.Another parallelly examining the serum CAM values in healthy people (control group, n=100).Compared the difference of the serum CAM levels in IS group with that of the control group and the differ-ence of the serum CAM levels in IS patients with different NIHSS score.The correlation of the CAM level in IS group with the NIHSS score were analyzed.Results:The serum CAM levels in IS group was significantly higher than control group(t=15.34,P<0.01).The serum CAM levels in the group A was significantly higher than the group B (t=10.51,P<0.01).The serum CAM level in acute IS patients with the NIHSS score were positively cor-related(r=0.308,P<0.01).Conclusion:The serum CAM levels can reflect the disease extent in patients with IS at acute phase.
