CAJ | 학술논문

目的探讨大剂量沐舒坦在食管癌围手术期应用中的临床效果.方法 80例食管癌患者随机平均分为两组,实验组40例在围手术期使用大剂量沐舒坦治疗,对照组40例使用常规剂量沐舒坦.结果对照组有1例失访；两组病例术后第1天呼吸功能均显著下降至术前的34.3％～42.6％,术后第3、第7、第14天呼吸功能逐渐恢复,最终能达到术前55.5％～82.5％,其中在术后第3及第7天实验组FEV％、第14天对照组VC％恢复优于对照组；肺功能不良事件发生率分别为7.5％(实验组)及10.3％(对照组),两组差异无统计学意义.结论在食管癌围手术期使用大剂量沐舒坦能够促进术后肺功能恢复.
목적 탐토대제량목서탄재식관암위수술기응용중적림상효과.방법 80례식관암환자수궤평균분위량조,실험조40례재위수술기사용대제량목서탄치료,대조조40례사용상규제량목서탄.결과 대조조유1례실방；량조병례술후제1천호흡공능균현저하강지술전적34.3％～42.6％,술후제3、제7、제14천호흡공능축점회복,최종능체도술전55.5％～82.5％,기중재술후제3급제7천실험조FEV％、제14천대조조VC％회복우우대조조；폐공능불량사건발생솔분별위7.5％(실험조)급10.3％(대조조),량조차이무통계학의의.결론 재식관암위수술기사용대제량목서탄능구촉진술후폐공능회복.
Objective To investigate the clinical efficacy of high-dose ambroxol during the perioperative period in esophageal cancer.Methods 80 patients with esophageal cancers were randomly divided into two groups.The study group (40 patients) received high-dose ambroxol,while the control group received normal dose ambroxol.Results One patient lost for follow-up in the control group.The respiratory function declined to 34.3％ to 42.6％ of the baseline on day one after surgery,gradually restored on days 3,7,and 14,and finally returned to 55.5％ to 82.5％.The study group was superior to the control group in FEV％ on days 3 and 7 and VC％ on day 14 after surgery.There was no significant difference between the two group in adverse events of lung function (7.5％ in the study group vs.10.3％ in the control group).Conclusions High-dose ambroxol during the perioperative period of in esophageal cancer can accelerate the postoperative restoration of lung function.