CAJ | 학술논문

目的：设计一种用于复发的胰腺癌和前列腺癌放射治疗的PLDR-IMRT计划。方法：选择10例复发胰腺癌和10例复发前列腺癌患者,每个计划设置10个非共面射野,采用各种优化手段使得计划满足PLDR治疗的要求。并与三维适形(PLDR-3DCRT)计划和旋转调强(PLDR-ARC)计划比较。结果：胰腺癌PLDR-IMRT计划中,每个单独的射野中PTV的平均剂量在17．6cGy到22．4cGy之间,最大剂量的范围从22．9cGy到34．8cGy。前列腺癌病例中,PTV在每个单独的射野中的平均剂量在18．8cGy 到22．6cGy 之间,最大剂量的范围从24．0cGy 到34．7cGy。 IMRT计划中危及器官的剂量大大小于三维适形计划,接近旋转调强计划。结论：在脉冲式低剂量率放射治疗中,通过优化的设计,IMRT计划相对于通常使用的3DCRT计划更有优势,在保证靶区剂量的基础上降低了危及器官受量。
목적：설계일충용우복발적이선암화전렬선암방사치료적PLDR-IMRT계화。방법：선택10례복발이선암화10례복발전렬선암환자,매개계화설치10개비공면사야,채용각충우화수단사득계화만족PLDR치료적요구。병여삼유괄형(PLDR-3DCRT)계화화선전조강(PLDR-ARC)계화비교。결과：이선암PLDR-IMRT계화중,매개단독적사야중PTV적평균제량재17．6cGy도22．4cGy지간,최대제량적범위종22．9cGy도34．8cGy。전렬선암병례중,PTV재매개단독적사야중적평균제량재18．8cGy 도22．6cGy 지간,최대제량적범위종24．0cGy 도34．7cGy。 IMRT계화중위급기관적제량대대소우삼유괄형계화,접근선전조강계화。결론：재맥충식저제량솔방사치료중,통과우화적설계,IMRT계화상대우통상사용적3DCRT계화경유우세,재보증파구제량적기출상강저료위급기관수량。
Objective: To investigate the planning techniques for IMRT-based PLDR treatment for recurrent pan-creatic and prostate cancer cases. Methods:Ten cases of recurrent recurrent pancreatic and 10 cases of prostate cancer pa-tients were included in this study. Treatment plans were generated with 10 gantry angles using the step-and-shot delivery technique, which can be delivered in three-minute intervals to achieve an effective low-dose rate. The IMRT plans were compared with the 3DCRT plans and ARC plans. Results:For the ten pancreas cases investigated, the mean PTV dose for each gantry angle in the IMRT plans ranged from 17. 6 cGy to 22. 4 cGy. The maximum doses ranged between 22. 9 cGy and 34. 8 cGy. For the ten prostate cases investigated, the mean PTV doses for individual gantry angles ranged from 18. 8 cGy to 22. 6 cGy. The maximum doses per gantry angle were between 24. 0 cGy and 34. 7 cGy. A significant reduction in the OAR dose was achieved with IMRT compared with 3DCRT. Conclusion:Compared with 3DCRT, IMRT could provide superior target coverage and normal tissue sparing for PLDR reirradiation of recurrent pancreatic and prostate cancers.