CAJ | 학술논문

目的：应用文献研究方法探讨谷胱甘肽硫转移酶M1（glutathione S-transferase M1，GSTM1）基因多态性与喉癌易感性的关系。方法全面检索ISI Web of Knowledge、Pubmed、Embase和中国期刊全文数据库等数据库，按照纳入和排除标准纳入文献，提取数据资料进行综合定量研究，并按照种族类别和对照来源进行亚组分析。结果最终纳入22篇文献，包含2535例喉癌患者和3233例对照样本。Meta分析显示，GSTM1空白基因型与喉癌易感性有统计学关联（OR=1.30，95％CI：1.07～1.57）。种族类别亚组分析显示GSTM1空白基因型与喉癌易感性在亚洲人群中有统计学关联（OR=1.68，95％CI：1.03～2.76），但在高加索人群中则否（OR=1.13，95％ CI：1.00～1.29）；按对照来源行亚组分析，提示以社区为基础的病例对照研究（OR=1.15，95％ CI：1.01～1.31）和以医院为基础的同类研究（OR=1.81，95％ CI：1.13～2.89）均显示这样的统计学关联性。结论 GSTM1基因多态性是喉癌发生的危险因素，并与人群种族类别有关。
목적：응용문헌연구방법탐토곡광감태류전이매M1（glutathione S-transferase M1，GSTM1）기인다태성여후암역감성적관계。방법전면검색ISI Web of Knowledge、Pubmed、Embase화중국기간전문수거고등수거고，안조납입화배제표준납입문헌，제취수거자료진행종합정량연구，병안조충족유별화대조래원진행아조분석。결과최종납입22편문헌，포함2535례후암환자화3233례대조양본。Meta분석현시，GSTM1공백기인형여후암역감성유통계학관련（OR=1.30，95％CI：1.07～1.57）。충족유별아조분석현시GSTM1공백기인형여후암역감성재아주인군중유통계학관련（OR=1.68，95％CI：1.03～2.76），단재고가색인군중칙부（OR=1.13，95％ CI：1.00～1.29）；안대조래원행아조분석，제시이사구위기출적병례대조연구（OR=1.15，95％ CI：1.01～1.31）화이의원위기출적동류연구（OR=1.81，95％ CI：1.13～2.89）균현시저양적통계학관련성。결론 GSTM1기인다태성시후암발생적위험인소，병여인군충족유별유관。
Objective To investigate the possible association of glutathione s-transferase M1 (GSTM1) gene polymorphism with laryngeal cancer susceptibility. Methods An overall literature review was carried out to search relevant papers through searching the nets of PubMed, Embase, ISI Web of Knowledge and Chinese National Knowledge Infrastructure, to select publications on the basis of established inclusion and exclusion criteria. Then, collected data were undergone a comprehensive quantitative analysis through a meta-analysis, combined also a sub-grouping study based on case’s ethnicity and controlling source of the cases. Results Twenty-two trials were included in the present view, including 2535 laryngeal cancer cases and 3233 controls. As shown from this met-analysis, GSTM1 null genotype was significantly associated with increased susceptibility of laryngeal cancer (OR=1.30, 95% CI: 1.07~1.57). When a stratifying study was made on the basis of race in this group of cases, GSTM1 null genotype exhibited an increased laryngeal cancer susceptibility in Asians (OR=1.68,95% CI:1.03~2.76), while no significant association was detected in Caucasians (OR=1.13, 95% CI: 1.00~1.29). When made a subgroup stratifying study in the same way based on the source of controls, significant association could be observed in either the population-based studies (OR=1.15, 95% CI: 1.01~1.31) or the hospital-based ones (OR=1.81, 95% CI:1.13~2.89). Conclusions This view, based on a meta-analysis, supports the known conclusion that GSTM1 gene polymorphism may associate with significantly increased laryngeal cancer susceptibility, particularly in Asians.