CAJ | 학술논문

膜转运体是调控细胞内外物质运输的一类功能蛋白，参与药物的吸收、分布和消除等体内过程，它也是维持机体内环境稳定的主要生物大分子，极易被各种化学物质所调控。本文对肾内26个已知转运体中研究较多的18种，如有机阴离子转运体、有机阳离子转运体和有机阴离子转运多肽等，从归属家族、分布、功能、底物及其选择性抑制剂等方面，对其在药物经肾清除过程中的核心作用以及由其引起的药物-药物相互作用的研究现状进行综述。
막전운체시조공세포내외물질운수적일류공능단백，삼여약물적흡수、분포화소제등체내과정，타야시유지궤체내배경은정적주요생물대분자，겁역피각충화학물질소조공。본문대신내26개이지전운체중연구교다적18충，여유궤음리자전운체、유궤양리자전운체화유궤음리자전운다태등，종귀속가족、분포、공능、저물급기선택성억제제등방면，대기재약물경신청제과정중적핵심작용이급유기인기적약물-약물상호작용적연구현상진행종술。
membrane transporters are a cIass of functionaI membrane proteins and mediate the absorption,distribution and eIimination of many drugs. They are biomoIecuIes responsibIe for the homeo-stasis,and they,however,are easiIy reguIated by many kinds of chemicaIs. The IocaIizations,func-tions,substrates and seIective inhibitors of 18 more understanding transporters among the 26 known ones in the kidney are summarized in this review. The impact of these transporters on drug disposition and the typicaI drug-drug interactions concerned are aIso discussed.