CAJ | 학술논문

茯苓、茯苓皮、猪苓和泽泻为常见的中药利尿药。茯苓中主要含茯苓三萜和茯苓多糖等成分，猪苓主要含甾体类成分，泽泻主要含四环三萜类成分。这些利尿药大多含有四环三萜或甾体类成分，它们的母核结构与醛固酮母核结构相似，其利尿作用机制可能是通过竞争醛固酮受体来抑制肾小管不同部位的重吸收，从而增加排尿量。本文对茯苓、茯苓皮、猪苓和泽泻的化学成分进行综述，并分析讨论其活性成分及利尿作用机制。
복령、복령피、저령화택사위상견적중약이뇨약。복령중주요함복령삼첩화복령다당등성분，저령주요함치체류성분，택사주요함사배삼첩류성분。저사이뇨약대다함유사배삼첩혹치체류성분，타문적모핵결구여철고동모핵결구상사，기이뇨작용궤제가능시통과경쟁철고동수체래억제신소관불동부위적중흡수，종이증가배뇨량。본문대복령、복령피、저령화택사적화학성분진행종술，병분석토론기활성성분급이뇨작용궤제。
Poria cocos,Cortex Poriae,Polyporusumbellatusand Alisma orientalisare common tra-ditionaI Chinese diuretic medicines. According to reported Iiterature,P.cocostriterpenes and poIysaccha-rides,steroids and tetracycIic triterpenes are the main chemicaI components of P.cocos,its epidermis, Pol.umbellatusand A.orientalis,respectiveIy. most of these diuretic drugs contain tetracycIic triterpenes and steroids,which have a simiIar structure to aIdosterone nucIeus structure. Therefore,this characteris-tic may reveaI their diuretic mechanisms. The tetracycIic triterpenes and steroids may exert diuretic effect through competitive inhibition of aIdosterone receptors in different parts of tubuIar reabsorption to increase urine output. The present articIe reviewed the chemicaI components of these diuretic Chinese medicines. Furthermore,their bioactive components and action mechanisms were aIso anaIyzed and discussed.