CAJ | 학술논문

纤维化是多种疾病的重要病理改变，其发病原因复杂，可导致正常组织功能的受损，甚至是丧失。尤其是重要脏器的纤维化严重影响患者生存质量，甚至危及生命，故针对不同脏器的纤维化治疗具有重要意义。不同器官纤维化发病原因不尽相同，但其基本机制是在炎症、免疫反应等刺激下，成纤维细胞增殖，导致胶原沉积。肝纤维化的治疗仍以中药为中心，重在缓解损伤，益气柔肝。由于目前尚无特效治愈肺纤维化的药物，故治疗仍以抗炎症为重点。肾纤维化的治疗主要针对缓解器质病变，改善肾功能而展开。虽然纤维化的治疗已取得了非常大的成果，但仍缺乏靶向性的药物。随着基因技术的发展，基因治疗也将成为疾病治疗的重要方向。本文综述了不同脏器纤维化的治疗药物，重点回顾了特异性作用于各脏器的药物。根据作用机制的不同，分类介绍了抗脏器纤维化的药物。
섬유화시다충질병적중요병리개변，기발병원인복잡，가도치정상조직공능적수손，심지시상실。우기시중요장기적섬유화엄중영향환자생존질량，심지위급생명，고침대불동장기적섬유화치료구유중요의의。불동기관섬유화발병원인불진상동，단기기본궤제시재염증、면역반응등자격하，성섬유세포증식，도치효원침적。간섬유화적치료잉이중약위중심，중재완해손상，익기유간。유우목전상무특효치유폐섬유화적약물，고치료잉이항염증위중점。신섬유화적치료주요침대완해기질병변，개선신공능이전개。수연섬유화적치료이취득료비상대적성과，단잉결핍파향성적약물。수착기인기술적발전，기인치료야장성위질병치료적중요방향。본문종술료불동장기섬유화적치료약물，중점회고료특이성작용우각장기적약물。근거작용궤제적불동，분류개소료항장기섬유화적약물。
Fibrosis is an important pathoIogicaI change in a variety of diseases and with compIicated causes. Fibrosis diseases in different organs have different causes,but the common manifestations of fibrobIast are proIiferation and coIIagen deposition that couId eventuaIIy Iead to normaI tissue damage and Ioss of function. Fibrosis in such important organs as the heart or Iung couId be Iife-threatening. There are different reguIating factors and drugs to fibrosis. Chinese medicine treatment is stiII the main method cIinicaIIy for Iiver fibrosis. Because there is no effective cure for puImonary fibrosis,treatment focuses on anti-infIammation by aIIeviating Iesion and improving kidney function. Despite the tremendous progress in fibrosis treatment,there is stiII a Iack of targeted drugs that couId cure a specific disease in a specific area. With the deveIopment of gene technoIogy,gene therapy wiII become an important treatment for this disease. This paper introduces anti-myocardiaI fibrosis drugs according to the mechanism.