CAJ | 학술논문

基础和临床研究已证实，抑郁症的发生与前额皮质和海马等脑区的神经可塑性功能异常有关，脑源性神经营养因子及其所介导的信号通路在神经可塑性调节以及抑郁症的发生中起重要作用。氯胺酮或东莨菪碱抗抑郁作用快速起效，长时程维持；它们通过快速激活脑源性神经营养因子相关信号通路，调节神经元可塑性，从而逆转抑郁样症状。本文就快速起效抗抑郁药的神经可塑性机制研究进行系统的综述，为今后新型抗抑郁药研发提供理论依据。
기출화림상연구이증실，억욱증적발생여전액피질화해마등뇌구적신경가소성공능이상유관，뇌원성신경영양인자급기소개도적신호통로재신경가소성조절이급억욱증적발생중기중요작용。록알동혹동랑탕감항억욱작용쾌속기효，장시정유지；타문통과쾌속격활뇌원성신경영양인자상관신호통로，조절신경원가소성，종이역전억욱양증상。본문취쾌속기효항억욱약적신경가소성궤제연구진행계통적종술，위금후신형항억욱약연발제공이론의거。
Basic and cIinicaI studies demonstrate that depression is associated with abnormaI neuraI pIasticity in some brain regions,incIuding the prefrontaI cortex and hippocampus. Brain-derived neurotro-phic factor(BDNF)and its signaIing pathways pIay a cruciaI roIe in reguIating neuraI pIasticity and deveI-opment of depression. Ketamine or scopoIamine can produce a quick and sustained antidepressant effect,and both can quictIy activate BDNF-signaIing pathways reIated to neuraI pIasticity. In order to pro-vide the theoreticaI basis for future researches on new antidepressants,the neuraI pIasticity mechanisms of faster-onset antidepressants are reviewed in this paper.