CAJ | 학술논문

目的：比较欧洲抗菌药物敏感试验委员会（European Committee on Antimicrobial Susceptibility Testing，EUCAST）和美国临床实验室标准化协会（Clinical and Laboratory Standards Institute，CLSI）微量稀释法检测曲霉体外药物敏感性的差异。方法分别用EUCAST方法和CLSI方法检测116株曲霉对两性霉素B、伏立康唑、伊曲康唑、卡泊芬净和米卡芬净的敏感性，比较两种方法的基本符合率、药敏符合率、极重大误差率和重大误差率。结果 EUCAST方法和CLSI方法对116株曲霉药敏检测的基本符合率为96．3％～100％。两方法检测烟曲霉对伏立康唑的药敏符合率98．8％，重大误差为1．2％，极重大误差率为0。烟曲霉和黑曲霉对两性霉素B以及烟曲霉和黄曲霉对伊曲康唑的药敏符合率均为100％，重大误差率和极重大误差率均为0。结论 EUCAST方法和CLSI方法对检测曲霉体外药物敏感性具有良好的一致性。
목적：비교구주항균약물민감시험위원회（European Committee on Antimicrobial Susceptibility Testing，EUCAST）화미국림상실험실표준화협회（Clinical and Laboratory Standards Institute，CLSI）미량희석법검측곡매체외약물민감성적차이。방법분별용EUCAST방법화CLSI방법검측116주곡매대량성매소B、복립강서、이곡강서、잡박분정화미잡분정적민감성，비교량충방법적기본부합솔、약민부합솔、겁중대오차솔화중대오차솔。결과 EUCAST방법화CLSI방법대116주곡매약민검측적기본부합솔위96．3％～100％。량방법검측연곡매대복립강서적약민부합솔98．8％，중대오차위1．2％，겁중대오차솔위0。연곡매화흑곡매대량성매소B이급연곡매화황곡매대이곡강서적약민부합솔균위100％，중대오차솔화겁중대오차솔균위0。결론 EUCAST방법화CLSI방법대검측곡매체외약물민감성구유량호적일치성。
Objective To compare the results of susceptibility testing by European Committee on Antimicrobial Susceptibility Testing (EUCAST)and Clinical and Laboratory Standards Institute (CLSI)broth microdilution methods against Aspergillus isolates.Methods The susceptibilities of 116 Aspergillus isolates were determined for amphotericin B, voriconazole, itraconazole,caspofungin and micafungin according to EUCAST (E.DEF 9.1 )and CLSI (M38-A2)methods.The essential agreement (EA),categorical agreement (CA),very major errors (VME)and major errors (ME)of the two methods were compared.Results The EA was 96.3%-100% between the two methods.The CA ,ME,and VME were 98.8%,0-1.2% and 0 respectively for the susceptibility of Aspergillus fumigatus to voriconazole.The CA,ME and VME was 1 00%,0 and 0 respectively for the susceptibility of Aspergillus fumigatus and Aspergillus niger to amphotericin B,or the susceptibility of Aspergillus fumigatus and Aspergillus flavus to itraconazole.Conclusions The results of susceptibility testing by EUCAST and CLSI broth microdilution methods are well consistent against Aspergillus isolates.