CAJ | 학술논문

目的：探讨非粒细胞缺乏肺曲霉病患者血清Dectin-1检测的临床意义。方法收集非粒细胞缺乏的曲霉病患者22例（肺曲霉病组），健康体检者54例（对照组），留取血清，ELISA方法检测两组血清 Dectin-1水平。分析 Dectin-1水平与血清1，3-D葡聚糖抗原检测（G试验）、半乳甘露聚糖抗原检测（GM试验）和血白细胞计数的关系。结果肺曲霉病组血清 Dectin-1水平为（427．2±42．6）pg/mL，对照组为（280．8±39．4）pg/mL，差异有统计学意义（P＜0．05）；Dectin-1水平与血白细胞计数、G试验、GM试验无相关性。结论在非粒细胞缺乏曲霉病患者血清中，Dectin-1水平明显增高，提示Dectin-1是重要的抗曲霉免疫分子。
목적：탐토비립세포결핍폐곡매병환자혈청Dectin-1검측적림상의의。방법수집비립세포결핍적곡매병환자22례（폐곡매병조），건강체검자54례（대조조），류취혈청，ELISA방법검측량조혈청 Dectin-1수평。분석 Dectin-1수평여혈청1，3-D포취당항원검측（G시험）、반유감로취당항원검측（GM시험）화혈백세포계수적관계。결과폐곡매병조혈청 Dectin-1수평위（427．2±42．6）pg/mL，대조조위（280．8±39．4）pg/mL，차이유통계학의의（P＜0．05）；Dectin-1수평여혈백세포계수、G시험、GM시험무상관성。결론재비립세포결핍곡매병환자혈청중，Dectin-1수평명현증고，제시Dectin-1시중요적항곡매면역분자。
Objective To explore the clinical implication of serum Dectin-1 level in the non-agranulocytic patients with pulmonary aspergillosis. Methods Serum specimen were collected from the non-agranulocytic patients with pulmonary aspergillosis to determine the serum level of Dectin-1 with ELISA.The relationship between serum Dectin-1 level,the results of G test and galactomannan (GM)test of Aspergillus,and white blood cell count was analyzed.Results The serum Dectin-1 level was (427.2 ± 42.6)pg/mL in the patients with Aspergillus infection,and (280.8 ± 39.4)pg/mL in the control patients (P<0.05 ).Dectin-1 level was not correlated to white blood cell count,or the result of G test,or GM test. Conclusions Serum Dectin-1 level increases significantly in the non-agranulocytic patients with pulmonary aspergillosis, suggesting that Dectin-1 is an important anti-Aspergillus immune molecule.