CAJ | 학술논문

目的：了解外周血小板计数增高对结核病患者病情的诊治价值。方法选择2012年1-6月住院初治肺结核进展期80例（进展期组）、治疗后好转期43例（好转期组）及同期健康体检者89名（对照组）。采用血常规细胞计数仪检测外周血白细胞、血小板计数，中性粒细胞比值；同日送检血红细胞沉降率（ESR）及 C反应蛋白（CRP）。SPSS13．0统计软件处理数据。结果进展期组 ESR及CRP分别明显高于好转期组（P＝0．0065，P＝0．0073）；进展期组血小板计数高于正常参考值上限者占41．94％，均值亦明显高于好转组及对照者（分别为P＝0．0014，P＝0．0000）；且血小板计数分别与 ESR及 CRP呈正相关。而白细胞计数及中性粒细胞比值与对照组比较差异无统计学意义（P＞0．05）。结论结核病患者外周血血小板计数升高，对判断病情的活动性及治疗效果具有一定参考价值。
목적：료해외주혈소판계수증고대결핵병환자병정적진치개치。방법선택2012년1-6월주원초치폐결핵진전기80례（진전기조）、치료후호전기43례（호전기조）급동기건강체검자89명（대조조）。채용혈상규세포계수의검측외주혈백세포、혈소판계수，중성립세포비치；동일송검혈홍세포침강솔（ESR）급 C반응단백（CRP）。SPSS13．0통계연건처리수거。결과진전기조 ESR급CRP분별명현고우호전기조（P＝0．0065，P＝0．0073）；진전기조혈소판계수고우정상삼고치상한자점41．94％，균치역명현고우호전조급대조자（분별위P＝0．0014，P＝0．0000）；차혈소판계수분별여 ESR급 CRP정정상관。이백세포계수급중성립세포비치여대조조비교차이무통계학의의（P＞0．05）。결론결핵병환자외주혈혈소판계수승고，대판단병정적활동성급치료효과구유일정삼고개치。
Objective To understand the role of increasing peripheral blood platelet count in the diagnosis and prognosis of patients with active pulmonary tuberculosis.Methods This analysis included 80 inpatients with active pulmonary tuberculosis evidenced by positive sputum smear,43 patients in recovery and 89 healthy controls during the period from January to June in 2012.Peripheral white blood cell,platelet count,and neutrophil percentage were assayed.Erythrocyte sedimentation rate (ESR)and serum C-reactive protein (CRP)were measured and compared.The data were analyzed by using SPSS 13.0 software.Results ESR and CRP values were significantly higher in the patients with active pulmonary tuberculosis than in the patients in recovery (P=0.006 5 and P=0.007 3,respectively).The peripheral blood platelet count exceeded normal range in 41.94% of the patients with active pulmonary tuberculosis,which was significantly higher than that in the patients in recovery (P=0.001 4)and controls (P=0.000 0).Platelet count was positively correlated with CPR (r=0.515,P<0.000 1)and ESR (r=0.398,P<0.001)value.However,peripheral white cell count and neutrophil count were not different from the corresponding values of controls.Conclusions Increasing peripheral platelet count may play a role in assessment of tuberculosis disease activity and the effect of anti-tuberculosis treatment.