CAJ | 학술논문

外体（exosome）是源自细胞内体的小囊泡，可由多种哺乳动物细胞分泌释放，其组分包括蛋白质、脂质、mRNA和microRNA，是细胞间“通讯”交互的工具之一。我们以介绍外体的组成和生物发生为基础，综述了近年来其在病毒感染致病中的研究成果，以期为病毒感染致病机理的研究提供新的切入点。
외체（exosome）시원자세포내체적소낭포，가유다충포유동물세포분비석방，기조분포괄단백질、지질、mRNA화microRNA，시세포간“통신”교호적공구지일。아문이개소외체적조성화생물발생위기출，종술료근년래기재병독감염치병중적연구성과，이기위병독감염치병궤리적연구제공신적절입점。
The exosome, as a nano vesicle that buds from the endosomal compartment, is produced and re-leased by all kinds of mammalian cells. This vesicle contains a variety of proteins, lipids, mRNA and microRNA. These components are specific to the origin of the exosomes and contribute to cell-cell communications. Most of the exosomes involved in viral infection can either spread or limit an infection based on the type of virus and its target cells. In this review, we introduced the exosome, its origin and function, then we discussed its roles in vi-ral infection which is involved in the fate of the infection.