癌症进展
癌癥進展
암증진전
ONCOLOGY PROGRESS
2014年
4期
360-364
,共5页
王骁%李立伟%王竞%魏正茂%马潞娜%金泉
王驍%李立偉%王競%魏正茂%馬潞娜%金泉
왕효%리립위%왕경%위정무%마로나%금천
胰腺癌%双时相%鉴别诊断%脱氧葡萄糖
胰腺癌%雙時相%鑒彆診斷%脫氧葡萄糖
이선암%쌍시상%감별진단%탈양포도당
pancreatic cancer%dual-time point%differential diagnose%deoxyglucose
目的：评价双时相显像在胰腺良恶性鉴别诊断中的应用价值。方法对24例胰腺癌患者和10例胰腺良性病变患者进行18F-FDG PET双时相显像（早注射FDG后50～60 min行早期显像，注射后120～150 min行延迟显像），测定两次显像病灶的标准摄取值（standard uptake value，SUV），并计算SUV变化率（ΔSUV）。结果胰腺癌组SUV 早期显像=4.63±2.09，SUV 延迟显像=5.86±2.74，ΔSUV=（24.76±15.58）%，差异有显著性（t=7.94，P<0.01）。而胰腺良性病变SUV 早期显像=2.48±0.95，SUV 延迟显像=2.81±1.18，ΔSUV=（12.66±20.97）%，差异有显著性（t=2.67，P<0.05），且胰腺癌组SUV 延迟显像明显高于良性病变组（t=2.25，P<0.05）。结论胰腺恶性病变SUV 延迟显像升高的幅度高于良性病变，但黏液腺癌SUV 延迟显像升高的幅度低于良性病变，总体而言，双时相显像方法简便，在临床上具有一定的实用价值。
目的：評價雙時相顯像在胰腺良噁性鑒彆診斷中的應用價值。方法對24例胰腺癌患者和10例胰腺良性病變患者進行18F-FDG PET雙時相顯像（早註射FDG後50～60 min行早期顯像，註射後120～150 min行延遲顯像），測定兩次顯像病竈的標準攝取值（standard uptake value，SUV），併計算SUV變化率（ΔSUV）。結果胰腺癌組SUV 早期顯像=4.63±2.09，SUV 延遲顯像=5.86±2.74，ΔSUV=（24.76±15.58）%，差異有顯著性（t=7.94，P<0.01）。而胰腺良性病變SUV 早期顯像=2.48±0.95，SUV 延遲顯像=2.81±1.18，ΔSUV=（12.66±20.97）%，差異有顯著性（t=2.67，P<0.05），且胰腺癌組SUV 延遲顯像明顯高于良性病變組（t=2.25，P<0.05）。結論胰腺噁性病變SUV 延遲顯像升高的幅度高于良性病變，但黏液腺癌SUV 延遲顯像升高的幅度低于良性病變，總體而言，雙時相顯像方法簡便，在臨床上具有一定的實用價值。
목적：평개쌍시상현상재이선량악성감별진단중적응용개치。방법대24례이선암환자화10례이선량성병변환자진행18F-FDG PET쌍시상현상（조주사FDG후50～60 min행조기현상，주사후120～150 min행연지현상），측정량차현상병조적표준섭취치（standard uptake value，SUV），병계산SUV변화솔（ΔSUV）。결과이선암조SUV 조기현상=4.63±2.09，SUV 연지현상=5.86±2.74，ΔSUV=（24.76±15.58）%，차이유현저성（t=7.94，P<0.01）。이이선량성병변SUV 조기현상=2.48±0.95，SUV 연지현상=2.81±1.18，ΔSUV=（12.66±20.97）%，차이유현저성（t=2.67，P<0.05），차이선암조SUV 연지현상명현고우량성병변조（t=2.25，P<0.05）。결론이선악성병변SUV 연지현상승고적폭도고우량성병변，단점액선암SUV 연지현상승고적폭도저우량성병변，총체이언，쌍시상현상방법간편，재림상상구유일정적실용개치。
Objective To assess the clinical value of dual-time point 18F-FDG PET imaging for differential diag-nosis between benign pancreatic mass and pancreaticcancer. Method Twenty-four patients with pancreatic cancer and 10 patients with benign pancreatic mass underwent dual-time 18F-FDG PET imaging. Prophase scans and delayed scans were administered 50-60 min and 120-150 min after the intravenous injection of 18F-FDG, respectively. The maximum standardized uptake value (SUV) and SUVvariation (ΔSUV) were calculated for the twotime points. Re-sult In pancreatic cancer group, SUVprophase= 4.63±2.09, SUVdelayed= 5.86±2.74, and ΔSUV =(24.76±15.58)%, with sig-nificant difference (t =7.94, P <0.01). While in benign pancreatic mass group,SUVprophase= 2.48±0.95, SUVdelayed= 2.81± 1.18, and ΔSUV =(12.66±20.97)%, with significant difference (t =2.67, P <0.05), and SUVdelayed in pancreatic cancer group was significantly higher than thati in benigh pancreatic mass group (t =2.25, P <0.05). Conclusion Compared with benign lesion, the elevatory extent of SUVdelayed for pancreatic malignant lesions ishigher, while it is lower in mu-cinous adenocarcinoma. As a convenient method, dual-time point18F-FDG PET imaging is recommended in clinical practice.
