CAJ | 학술논문

目的：探讨葡萄胎行清宫术及预防性化疗的临床效果。方法选取成都市新都区人民医院2005~2011年收治的具有高危恶变因素的葡萄胎患者113例作为研究对象，分为观察组41例，对照组72例。两组行超声引导下清宫术，观察组术后给予预防性化疗，对照组术后未作化疗，比较两组临床疗效。结果观察组恶变率低于对照组(P＜0.05)；观察组化疗后期不良反应在停药及对症治疗后，均逐渐得到改善和缓解。结论对于具有高危恶变因素的葡萄胎患者，彻底的清除葡萄胎病变组织，同时给予预防性化疗，可以有效预防发生恶变。
목적：탐토포도태행청궁술급예방성화료적림상효과。방법선취성도시신도구인민의원2005~2011년수치적구유고위악변인소적포도태환자113례작위연구대상，분위관찰조41례，대조조72례。량조행초성인도하청궁술，관찰조술후급여예방성화료，대조조술후미작화료，비교량조림상료효。결과관찰조악변솔저우대조조(P＜0.05)；관찰조화료후기불량반응재정약급대증치료후，균축점득도개선화완해。결론대우구유고위악변인소적포도태환자，철저적청제포도태병변조직，동시급여예방성화료，가이유효예방발생악변。
Objective To investigate the effect of dilatation and curettage and preventive chemotherapy for hydatid mole. Methods 113 patients of hydatid mole with risk factors of malignant transformation in The People 's Hospital of Xindu District Hospital from January 2005 to December 2011 were selected,all patients were divided into observation group with 41 cases and control group with 72 cases. Patients in observation group were undergone the dilatation and curettage guided by ultrasound and postoperative preventive chemotherapy. Patients in control group were given the only dilatation and curettage guided by ultrasound. Clinical effect of two groups were compared. Results The rate of malignant transformation in observation group was lower than control group ( P<0. 05 ) . The toxicity of chemotherapy in the observation group alleviated with drug withdrawal and symptomatic treatment. Conclusion For hydatid mole with risk factors of malignant transformation, it can effectively prevent the occurrence of malignant transformation through dilatation and curettage and preventive chemotherapy.