中国神经精神疾病杂志
中國神經精神疾病雜誌
중국신경정신질병잡지
CHINESE JOURNAL OF NERVOUS AND MENTAL DISEASES
2014年
6期
362-367
,共6页
张程程%李名立%李娜%雷威%黄朝华%邓伟%王强%马小红%李涛
張程程%李名立%李娜%雷威%黃朝華%鄧偉%王彊%馬小紅%李濤
장정정%리명립%리나%뢰위%황조화%산위%왕강%마소홍%리도
精神分裂症%灰质%磁共振
精神分裂癥%灰質%磁共振
정신분렬증%회질%자공진
Schizophrenia%Grey matter%MRI
目的:探讨青少年首发未用药精神分裂症患者的脑灰质结构损害特征及其与临床特征的相关性。方法应用GE 3.0T磁共振成像仪对26例青少年首发精神分裂症患者与26名青少年正常对照进行头颅结构磁共振扫描获得3D脑结构图像,采用基于变形场理论的最新形态学配准技术(diffeomorphic anatomi-cal registration using the exponentiated lie algebra ,DARTEL)对脑灰质体积进行分析,并对患者异常的灰质体积与临床症状严重程度进行相关性分析。结果与对照组相比,患者组灰质体积下降区域为左侧顶叶中央后回、边缘叶海马旁回以及右侧小脑后叶蚓锥体,两组间差异均有统计学意义(P<0.001,未校正)。偏相关分析显示,左侧海马旁回灰质体积与PANSS偏执分(r=-0.49,P=0.02)存在相关,余灰质损害脑区与临床特征均无统计学相关性(P>0.05)。结论青少年首发精神分裂症患者脑结构损害模式为小脑-边缘叶(海马旁回)-顶叶的脑结构异常,患者的偏执症状与左侧海马旁回灰质损害有关。
目的:探討青少年首髮未用藥精神分裂癥患者的腦灰質結構損害特徵及其與臨床特徵的相關性。方法應用GE 3.0T磁共振成像儀對26例青少年首髮精神分裂癥患者與26名青少年正常對照進行頭顱結構磁共振掃描穫得3D腦結構圖像,採用基于變形場理論的最新形態學配準技術(diffeomorphic anatomi-cal registration using the exponentiated lie algebra ,DARTEL)對腦灰質體積進行分析,併對患者異常的灰質體積與臨床癥狀嚴重程度進行相關性分析。結果與對照組相比,患者組灰質體積下降區域為左側頂葉中央後迴、邊緣葉海馬徬迴以及右側小腦後葉蚓錐體,兩組間差異均有統計學意義(P<0.001,未校正)。偏相關分析顯示,左側海馬徬迴灰質體積與PANSS偏執分(r=-0.49,P=0.02)存在相關,餘灰質損害腦區與臨床特徵均無統計學相關性(P>0.05)。結論青少年首髮精神分裂癥患者腦結構損害模式為小腦-邊緣葉(海馬徬迴)-頂葉的腦結構異常,患者的偏執癥狀與左側海馬徬迴灰質損害有關。
목적:탐토청소년수발미용약정신분렬증환자적뇌회질결구손해특정급기여림상특정적상관성。방법응용GE 3.0T자공진성상의대26례청소년수발정신분렬증환자여26명청소년정상대조진행두로결구자공진소묘획득3D뇌결구도상,채용기우변형장이론적최신형태학배준기술(diffeomorphic anatomi-cal registration using the exponentiated lie algebra ,DARTEL)대뇌회질체적진행분석,병대환자이상적회질체적여림상증상엄중정도진행상관성분석。결과여대조조상비,환자조회질체적하강구역위좌측정협중앙후회、변연협해마방회이급우측소뇌후협인추체,량조간차이균유통계학의의(P<0.001,미교정)。편상관분석현시,좌측해마방회회질체적여PANSS편집분(r=-0.49,P=0.02)존재상관,여회질손해뇌구여림상특정균무통계학상관성(P>0.05)。결론청소년수발정신분렬증환자뇌결구손해모식위소뇌-변연협(해마방회)-정협적뇌결구이상,환자적편집증상여좌측해마방회회질손해유관。
Objective To investigate gray matter structural damage in first-episode antipsychotic-na?ve patients with adolescent-onset schizophrenia. Methods Twenty-six patients with schizophrenia and 26 healthy controls were scanned by using GE 3.0T magnetic resonance imaging in order to explore brain gray matter volume (GMV) changes with registration techniques based on the latest morphological deformation field theory. The correlation of gray matter volume abnormalities with clinical severity was also analyzed. Results Compared with healthy controls, patients with adoles-cent-onset schizophrenia showed significant reduction in GMV in the left parietal lobe, parahippocampal gyrus and right cerebellar pyramis. GMV of the left parahippocampal gyrus is significantly correlated with PANSS paranoid scores (r=-0.49, P=0.02). Conclusions There is structural abnormality in GM in parahippocampal-parietal-cerebellar in pa-tients with adolescent-onset schizophrenia and the severity of paranoid symptoms is related to the reduced GMV in the left parahippocampal gyrus.