中国神经精神疾病杂志
中國神經精神疾病雜誌
중국신경정신질병잡지
CHINESE JOURNAL OF NERVOUS AND MENTAL DISEASES
2014年
6期
348-352
,共5页
陈略%朱飞奇%刘纯钢%朱瑾华
陳略%硃飛奇%劉純鋼%硃瑾華
진략%주비기%류순강%주근화
联合降脂%盐酸小檗碱%阿托伐他汀%血脂%颈动脉粥样硬化斑块
聯閤降脂%鹽痠小檗堿%阿託伐他汀%血脂%頸動脈粥樣硬化斑塊
연합강지%염산소벽감%아탁벌타정%혈지%경동맥죽양경화반괴
Combination lipid lowering therapy%Berberine hydrochloride%Atorvastatin%Blood fat%Carotid ath-erosclerotic plaque
目的：观察盐酸小檗碱联合阿托伐他汀对急性脑梗死患者血脂水平和颈动脉粥样硬化斑块的影响。方法55例急性脑梗死患者随机分为A组（n=28）、B组（n=11）、C组（n=16），分别使用阿托伐他汀20 mg/d，阿托伐他汀40 mg/d和阿托伐他汀20 mg/d+黄连素0.4g(3次/d)治疗，随访3个月，比较3组的总胆固醇（total cho-lesterol，TC）、甘油三酯（triglycerides，TG）、低密度脂蛋白胆固醇（low-density lipoprotein cholesterol，LDL-C）、高密度脂蛋白胆固醇（high-density lipoprotein cholesterol，HDL-C），以及颈动脉粥样硬化斑块总面积（total plaque ar-ea，TPA）、斑块总最大厚度之和（Crouse积分）、内膜中层厚度（intima-media thickness，IMT）、不稳定性斑块数目的差异。结果治疗3个月后，3组的TC、TG、LDL-C均有下降，且TC和LDL-C 3组间的比较具有统计学差异（P=0.011，P=0.033）；比较3组LDL-C的达标率，C组（75.0%）明显高于A组（32.1%）和B组（45.5%），差异有统计学意义（P=0.026）；A、C两组均可显著降低Crouse积分（P<0.05），治疗后C组的Crouse积分明显低于A组，且两组间的比较差异具有统计学意义（P<0.05）,而B组的Crouse积分出现升高。结论黄连素显著提高阿托伐他汀降低脑梗死患者LDL-C的幅度和达标率，并降低颈动脉粥样硬化斑块总最大厚度之和。
目的：觀察鹽痠小檗堿聯閤阿託伐他汀對急性腦梗死患者血脂水平和頸動脈粥樣硬化斑塊的影響。方法55例急性腦梗死患者隨機分為A組（n=28）、B組（n=11）、C組（n=16），分彆使用阿託伐他汀20 mg/d，阿託伐他汀40 mg/d和阿託伐他汀20 mg/d+黃連素0.4g(3次/d)治療，隨訪3箇月，比較3組的總膽固醇（total cho-lesterol，TC）、甘油三酯（triglycerides，TG）、低密度脂蛋白膽固醇（low-density lipoprotein cholesterol，LDL-C）、高密度脂蛋白膽固醇（high-density lipoprotein cholesterol，HDL-C），以及頸動脈粥樣硬化斑塊總麵積（total plaque ar-ea，TPA）、斑塊總最大厚度之和（Crouse積分）、內膜中層厚度（intima-media thickness，IMT）、不穩定性斑塊數目的差異。結果治療3箇月後，3組的TC、TG、LDL-C均有下降，且TC和LDL-C 3組間的比較具有統計學差異（P=0.011，P=0.033）；比較3組LDL-C的達標率，C組（75.0%）明顯高于A組（32.1%）和B組（45.5%），差異有統計學意義（P=0.026）；A、C兩組均可顯著降低Crouse積分（P<0.05），治療後C組的Crouse積分明顯低于A組，且兩組間的比較差異具有統計學意義（P<0.05）,而B組的Crouse積分齣現升高。結論黃連素顯著提高阿託伐他汀降低腦梗死患者LDL-C的幅度和達標率，併降低頸動脈粥樣硬化斑塊總最大厚度之和。
목적：관찰염산소벽감연합아탁벌타정대급성뇌경사환자혈지수평화경동맥죽양경화반괴적영향。방법55례급성뇌경사환자수궤분위A조（n=28）、B조（n=11）、C조（n=16），분별사용아탁벌타정20 mg/d，아탁벌타정40 mg/d화아탁벌타정20 mg/d+황련소0.4g(3차/d)치료，수방3개월，비교3조적총담고순（total cho-lesterol，TC）、감유삼지（triglycerides，TG）、저밀도지단백담고순（low-density lipoprotein cholesterol，LDL-C）、고밀도지단백담고순（high-density lipoprotein cholesterol，HDL-C），이급경동맥죽양경화반괴총면적（total plaque ar-ea，TPA）、반괴총최대후도지화（Crouse적분）、내막중층후도（intima-media thickness，IMT）、불은정성반괴수목적차이。결과치료3개월후，3조적TC、TG、LDL-C균유하강，차TC화LDL-C 3조간적비교구유통계학차이（P=0.011，P=0.033）；비교3조LDL-C적체표솔，C조（75.0%）명현고우A조（32.1%）화B조（45.5%），차이유통계학의의（P=0.026）；A、C량조균가현저강저Crouse적분（P<0.05），치료후C조적Crouse적분명현저우A조，차량조간적비교차이구유통계학의의（P<0.05）,이B조적Crouse적분출현승고。결론황련소현저제고아탁벌타정강저뇌경사환자LDL-C적폭도화체표솔，병강저경동맥죽양경화반괴총최대후도지화。
Objective To observe influence of atorvastatin combining with berberine on blood cholesterol level and carotid atherosclerotic plaques in patients with acute artery atherosclerosis cerebral infarction disease. Methods Fif-ty-five cases of acute cerebral infarction patients were randomized into 3 groups: group A (n=28), group B (n=11) and group C (n=16). Group A, B or C received atorvastatin 20 mg (qn), atorvastatin 40 mg (qn) or atorvastatin 20 mg (qn) +berberine 0.4 g (tid), respectively. All groups were then followed up for 3 months. The total cholesterol(TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C),high-density lipoprotein-cholesterol(HDL-C and the changes of carotid atherosclerotic plaques including total plaque area (TPA), crouse score,carotid intima-media thickness (IMT) and the stability of carotid plaques as well as the serum levels of creatinine(Scr), alanine aminotransferase(ALT), aspartate aminotransferase(AST), were compared among three groups. Results After 3 months, the TC, TG and LDL-C were de-creased in all three groups. There were statistically significant differences in the TC and LDL-C among these three groups (P=0.011,P=0.033) after treatment. The compliance rate of group C (75.0%) was significantly higher than group A ( 32.1% ) and group B (45.5%) in LDL-C (P=0.026). Both berberine combining with atorvastatin and atorvastatin monotherapy(20mg could significantly reduce crouse score. Conclusions Berberine can significantly enhance the benefi-cial effects of atorvastatin on LDL-C and the crouse score in patients with acute artery atherosclerosis cerebral infarction patients.
