中国神经精神疾病杂志
中國神經精神疾病雜誌
중국신경정신질병잡지
CHINESE JOURNAL OF NERVOUS AND MENTAL DISEASES
2014年
6期
341-347
,共7页
轻度认知障碍%Meta分析%Tau蛋白β-淀粉样蛋白
輕度認知障礙%Meta分析%Tau蛋白β-澱粉樣蛋白
경도인지장애%Meta분석%Tau단백β-정분양단백
Mild cognitive impairment (MCI)%Meta-analysis%Tau protein%β-amyloid
目的：采用Meta分析方法研究轻度认知障碍(mild cognitive impairment, MCI)患者脑脊液总tau (total tau, T-tau)蛋白及β淀粉样蛋白42(β-amyloid 42，Aβ42)水平的改变。方法计算机检索Pubmed、Cochrane临床试验数据库，Ovid全文电子期刊、中国知网全文数据库、维普中文期刊数据库及万方等数据库中关于MCI患者中脑脊液T-tau蛋白及Aβ42变化的病例-对照研究，采用Review Manager 5.2软件对数据进行Meta分析。结果共有17篇文献纳入分析。Meta分析结果显MCI患者脑脊液中T-tau蛋白水平显著高于对照组(MD=113.10,95%CI=87.93~138.26)；而脑脊液中Aβ42水平明显低于正常对照组(MD=-146.50,95%CI=-178.70~-114.29)，且两者的改变均有统计学差异(P<0.01)。结论MCI患者脑脊液T-tau蛋白水平明显增高，而Aβ42水平明显下降。
目的：採用Meta分析方法研究輕度認知障礙(mild cognitive impairment, MCI)患者腦脊液總tau (total tau, T-tau)蛋白及β澱粉樣蛋白42(β-amyloid 42，Aβ42)水平的改變。方法計算機檢索Pubmed、Cochrane臨床試驗數據庫，Ovid全文電子期刊、中國知網全文數據庫、維普中文期刊數據庫及萬方等數據庫中關于MCI患者中腦脊液T-tau蛋白及Aβ42變化的病例-對照研究，採用Review Manager 5.2軟件對數據進行Meta分析。結果共有17篇文獻納入分析。Meta分析結果顯MCI患者腦脊液中T-tau蛋白水平顯著高于對照組(MD=113.10,95%CI=87.93~138.26)；而腦脊液中Aβ42水平明顯低于正常對照組(MD=-146.50,95%CI=-178.70~-114.29)，且兩者的改變均有統計學差異(P<0.01)。結論MCI患者腦脊液T-tau蛋白水平明顯增高，而Aβ42水平明顯下降。
목적：채용Meta분석방법연구경도인지장애(mild cognitive impairment, MCI)환자뇌척액총tau (total tau, T-tau)단백급β정분양단백42(β-amyloid 42，Aβ42)수평적개변。방법계산궤검색Pubmed、Cochrane림상시험수거고，Ovid전문전자기간、중국지망전문수거고、유보중문기간수거고급만방등수거고중관우MCI환자중뇌척액T-tau단백급Aβ42변화적병례-대조연구，채용Review Manager 5.2연건대수거진행Meta분석。결과공유17편문헌납입분석。Meta분석결과현MCI환자뇌척액중T-tau단백수평현저고우대조조(MD=113.10,95%CI=87.93~138.26)；이뇌척액중Aβ42수평명현저우정상대조조(MD=-146.50,95%CI=-178.70~-114.29)，차량자적개변균유통계학차이(P<0.01)。결론MCI환자뇌척액T-tau단백수평명현증고，이Aβ42수평명현하강。
Objective To evaluate the changes of the level of cerebrospinal fluid T-tau protein andβ-amyloid 42 in mild cognitive impairment (MCI) patients. Methods Computer retrieval was preformed for cerebrospinal fluid (CSF) to-tal tau protein (T-tau) and β-amyloid 42 (Aβ 42) levels among MCI and healthy people in Pubmed, Cochrane Library, Ovid, CNKI, VIP Data and Wangfang Data. Meta-analyses were conducted on the T-tau and Aβ42 levels using Review Manager 5.2 software. Results Seventeen studies met inclusion criteria. Meta-analysis results showed that, CSF T-tau protein levels were significantly higher (MD:113.10;95%CI:87.93-138.26) and Aβ42 levels were significantly lower in the patients with MCI, (MD=-146.50;95%CI=-178.70- -114.29) compared with the control group (P<0.01). Conclu-sions T-tau significantly increases while Aβ42 significantly decreases in the CSF in patients with MCI.
