CAJ | 학술논문

目的：探讨怀孕对甲状腺微小乳头状癌进展的影响。方法选择2000年1月~2013年12月12例孕期诊断为甲状腺微小乳头状癌的患者，同时选取20例非孕期的甲状腺微小乳头状癌的患者作为对照。随访期间监测肿瘤大小、Tg以及 TSH 的水平变化。结果孕期甲状腺微小乳头状癌患者的肿瘤大小由诊断时（6.2±2.1）mm 增长至产后6个月的（9.2±4.4）mm，此时显著大于对照组肿瘤大小[（6.9±4.5）mm，P ﹤0.05]。甲状腺微小乳头状癌患者 Tg 水平在孕中期为（33.59±10.23）ng/ ml，显著高于诊断时水平[（12.34±4.23）ng/ ml，P ﹤0.05]；TSH 水平在孕中期为（0.3±0.1）μIU/ ml，也显著高于诊断时水平[（3.5±1.2）μIU/ ml，P ﹤0.05]。结论怀孕期间，甲状腺微小乳头状癌患者的肿瘤显著增大，Tg 及 TSH水平显著增高。因此，对甲状腺微小乳头状癌患者应该密切随访，尤其是在孕早期。
목적：탐토부잉대갑상선미소유두상암진전적영향。방법선택2000년1월~2013년12월12례잉기진단위갑상선미소유두상암적환자，동시선취20례비잉기적갑상선미소유두상암적환자작위대조。수방기간감측종류대소、Tg이급 TSH 적수평변화。결과잉기갑상선미소유두상암환자적종류대소유진단시（6.2±2.1）mm 증장지산후6개월적（9.2±4.4）mm，차시현저대우대조조종류대소[（6.9±4.5）mm，P ﹤0.05]。갑상선미소유두상암환자 Tg 수평재잉중기위（33.59±10.23）ng/ ml，현저고우진단시수평[（12.34±4.23）ng/ ml，P ﹤0.05]；TSH 수평재잉중기위（0.3±0.1）μIU/ ml，야현저고우진단시수평[（3.5±1.2）μIU/ ml，P ﹤0.05]。결론부잉기간，갑상선미소유두상암환자적종류현저증대，Tg 급 TSH수평현저증고。인차，대갑상선미소유두상암환자응해밀절수방，우기시재잉조기。
Objective To discuss the impact of pregnancy on thyroid papillary microcarcinoma. Methods 12 patients with thyroid papillary microcarcinoma in pregnancy and 20 female patients with thyroid papillary microcarcinoma as the control were enrolled in this study;the size of the tumors,the levels of Tg and TSH in all the cases was monitored in follow-up. Results The size of tumors significantly enlarged[(6.2 ± 2. 1)mm vs(9. 2 ± 4. 4)mm,P ﹤ 0. 05]during pregnancy;the level of Tg increased during middle pregnancy[(33.59 ± 10.23)ng/ ml vs(12.34 ± 4. 23)ng/ ml,P ﹤ 0. 05];and the same change was detected in the level of TSH[(0. 3 ± 0. 1)μIU/ ml vs(3.5 ± 1.2)μIU/ ml,P ﹤0. 05]. Conclusions The size of the tumor gets enlarged greatly in patients with thyroid papillary microcarcinoma in pregnancy and the levels of Tg and TSH rise up;a careful follow-up should be made,especially during early pregnancy.