天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2014年
8期
840-842
,共3页
田垚%陈璐%张斌%曹旭晨
田垚%陳璐%張斌%曹旭晨
전요%진로%장빈%조욱신
乳腺肿瘤%DNA结合蛋白质%转录因子%受体,雌激素%骨肿瘤%Runx2%骨转移%综述
乳腺腫瘤%DNA結閤蛋白質%轉錄因子%受體,雌激素%骨腫瘤%Runx2%骨轉移%綜述
유선종류%DNA결합단백질%전록인자%수체,자격소%골종류%Runx2%골전이%종술
breast neoplasms%DNA-binding proteins%transcription factors%receptors,estrogen%bone neoplasms%Runx2%bone metastases%review
Runx2是转录因子RUNXX家族成员之一,其作为参与乳腺组织中某些基因表达调控的重要因子之一,在乳腺上皮细胞分化过程中发挥重要作用,并与乳腺肿瘤细胞株的侵袭性密切相关。Runx2的过表达还与乳腺癌的某些特征相关。本文就Runx2在乳腺癌中作用的相关研究进展综述如下。
Runx2是轉錄因子RUNXX傢族成員之一,其作為參與乳腺組織中某些基因錶達調控的重要因子之一,在乳腺上皮細胞分化過程中髮揮重要作用,併與乳腺腫瘤細胞株的侵襲性密切相關。Runx2的過錶達還與乳腺癌的某些特徵相關。本文就Runx2在乳腺癌中作用的相關研究進展綜述如下。
Runx2시전록인자RUNXX가족성원지일,기작위삼여유선조직중모사기인표체조공적중요인자지일,재유선상피세포분화과정중발휘중요작용,병여유선종류세포주적침습성밀절상관。Runx2적과표체환여유선암적모사특정상관。본문취Runx2재유선암중작용적상관연구진전종술여하。
Runx2 is a transcription factor belongs to RUNXX family, and it is one of the important factors involved in expression and participation in regulation of mammary specific genes in the mammary gland. The overexpression is also as-sociated with certain characteristics of breast cancer. This article aims to summarize the recent progress of the role that Runx2 plays in breast cancer.