CAJ | 학술논문

目的：探讨表皮样囊肿癌变的临床特点、病理形态、免疫组化及预后等。方法收集6例表皮样囊肿癌变资料，分析其临床特点，观察病理形态及免疫组化表型，通过随访了解其预后。结果临床表现均为局部包块，行扩大切除，随访1年，无复发和转移。病理检查示为不整形肿块，囊性，内为豆渣样物，镜检示囊内为变性层状角质物，囊壁衬覆鳞状上皮，癌变区鳞状上皮呈巢团状间质浸润。病理诊断表皮样囊肿癌变为鳞状细胞癌。免疫表型：6例癌变鳞状细胞CK5/6、P63阳性。结论表皮样囊肿癌变非常少见，诊断主要靠常规病理切片确诊，免疫组化标记协助诊断，局部适当扩大切除为首选，其恶性程度较低，预后较好。
목적：탐토표피양낭종암변적림상특점、병리형태、면역조화급예후등。방법수집6례표피양낭종암변자료，분석기림상특점，관찰병리형태급면역조화표형，통과수방료해기예후。결과림상표현균위국부포괴，행확대절제，수방1년，무복발화전이。병리검사시위불정형종괴，낭성，내위두사양물，경검시낭내위변성층상각질물，낭벽츤복린상상피，암변구린상상피정소단상간질침윤。병리진단표피양낭종암변위린상세포암。면역표형：6례암변린상세포CK5/6、P63양성。결론표피양낭종암변비상소견，진단주요고상규병리절편학진，면역조화표기협조진단，국부괄당확대절제위수선，기악성정도교저，예후교호。
Objective To study and research the clinical pathologic features, immunohistochemistry and prognosis of epidermoid cyst with cancerous changes. Methods Six cases of epidermoid cyst with cancerous changes were studied of their clinical pathologic features and immunohistochemistic expression and their prognosis was evaluated by follow-up vis-its. Results Clinical features: All six cases showed local enclosed mass and underwent extensive resection. No recur-rence nor metastasis were shown in one year follow up. Pathological examination show irregular cystic mass with bean curd like fillings in it. Microscopic examination showed those cysts were lined with squamous epithelium which indicate invasive growth. Pathological diagnosis: Epidermoid cyst canceration to squamous cell carcinoma. Immuno-phenotype: CK 5/6 and P63 were positive in all six squamous cell cancer cases. Conclusion Epidermoid cyst with cancerous changes are quite rare. Diagnosis of the tumor largely relies on histopathology and immunohistochemical markers also assist diagnosis. Local appropriate expanded resection is preferred. Its malignant degree is low and prognosis is good.