CAJ | 학술논문

目的：通过构建新西兰大白兔腰椎脊柱结核疾病模型,比较分析 MRI、CT、X 线平片3种影像手段在早期脊柱结核中的诊断价值。方法选择健康成年新西兰白兔40只,分为感染组(30只)和对照组(10只),应用外科手术建立兔脊柱结核动物模型,术后4、6、8周时行影像学、组织病理学等检查。结果 X 线平片、CT、MRI 显示脊柱结核病变的敏感性分别为46.13%、76.3%和92.3%；对于单个椎体结核病灶破坏范围的确定,MRI 和 CT 较 X 线平片有明显优势(P <0.05)；应用传统的 MRI 联合 DWI 检查方法可以早期发现椎体是否感染结核。感染组阳性兔的椎体、椎旁软组织切片 HE 染色示有脓细胞、类上皮样细胞或坏死灶等形成。结论 X 线平片、CT、MRI 3种影像学方法能够为脊柱结核早期诊断提供一定信息,MRI 扫描对脊柱结核早期诊断比其他影像学检查更为敏感。
목적：통과구건신서란대백토요추척주결핵질병모형,비교분석 MRI、CT、X 선평편3충영상수단재조기척주결핵중적진단개치。방법선택건강성년신서란백토40지,분위감염조(30지)화대조조(10지),응용외과수술건립토척주결핵동물모형,술후4、6、8주시행영상학、조직병이학등검사。결과 X 선평편、CT、MRI 현시척주결핵병변적민감성분별위46.13%、76.3%화92.3%；대우단개추체결핵병조파배범위적학정,MRI 화 CT 교 X 선평편유명현우세(P <0.05)；응용전통적 MRI 연합 DWI 검사방법가이조기발현추체시부감염결핵。감염조양성토적추체、추방연조직절편 HE 염색시유농세포、류상피양세포혹배사조등형성。결론 X 선평편、CT、MRI 3충영상학방법능구위척주결핵조기진단제공일정신식,MRI 소묘대척주결핵조기진단비기타영상학검사경위민감。
Objective To investigate the value of X-ray,CT and MRI in diagnosing early spinal tuberculosis by constructing lum-bar vertebra tuberculosis model in New Zealand rabbits.Methods Forty healthy New Zealand rabbits were randomly divided into the infected group (n=30)and the control group (n= 10).All rabbits were performed lumbar vertebra surgery,and then underwent imaging and histopathologic examination at 4,6,8 weeks respectively.Results The sensitivity of X-ray,CT and MRI in detecting tuberculosis lesions were 46.13%,76.3%,and 92.3%,respectively.MRI and CT were better than X-ray for displaying the de-struction range limited in a single vertebra (P <0.05).Combination with routine MRI and diffusion-weighted imaging (DWI)could find the vertebra tuberculosis at the early stage.According to the HE staining,pus cells,epithelioid cells or necrosis were seen in the tissue sections of vertebra and paraspinal soft tissues in the infected group.Conclusion X-ray,CT and MRI could provide some information for the early diagnosis of spinal tuberculosis,and MRI is more sensitive.