CAJ | 학술논문

目的：探讨磁共振 DWI 在 Marchiafava-Bignami 病(MBD)中的诊断价值和临床意义。方法(1)12例 MBD 患者(随访6个月)及12例健康成人行 MRI DWI 扫描；(2)观察 MBD 患者大脑结构受累情况及胼胝体、胼胝体外灰白质受累 MRI 表现；(3)测量胼胝体中央区、相对边缘区、胼胝体外灰白质 ADC 值,进行完全随机设计方差分析。结果12例 MBD 患者 DWI 序列胼胝体表现为高信号,11例 T2 WI 矢状位胼胝体呈典型的“三明治征”,6例累及胼胝体以外的灰白质；对照组与 MBD 症状好转组、无好转组胼胝体中央区、相对边缘区、胼胝体外灰质 ADC 值差异有统计学意义(P 值<0.05)；对照组与 MBD 症状好转组、无好转组胼胝体外白质结构 ADC 值差异无统计学意义。结论 DWI 可用于反映 MBD 微观结构的改变；胼胝体和皮层低的 ADC 值与不良预后密切相关。
목적：탐토자공진 DWI 재 Marchiafava-Bignami 병(MBD)중적진단개치화림상의의。방법(1)12례 MBD 환자(수방6개월)급12례건강성인행 MRI DWI 소묘；(2)관찰 MBD 환자대뇌결구수루정황급변지체、변지체외회백질수루 MRI 표현；(3)측량변지체중앙구、상대변연구、변지체외회백질 ADC 치,진행완전수궤설계방차분석。결과12례 MBD 환자 DWI 서렬변지체표현위고신호,11례 T2 WI 시상위변지체정전형적“삼명치정”,6례루급변지체이외적회백질；대조조여 MBD 증상호전조、무호전조변지체중앙구、상대변연구、변지체외회질 ADC 치차이유통계학의의(P 치<0.05)；대조조여 MBD 증상호전조、무호전조변지체외백질결구 ADC 치차이무통계학의의。결론 DWI 가용우반영 MBD 미관결구적개변；변지체화피층저적 ADC 치여불량예후밀절상관。
Objective To study the value of diffusion weighted imaging (DWI)in Marchiafava-Bignami disease.Methods (1)12 cases of Marchiafava-Bignami disease (MBD)patients with 6 month follow-up and 12 hedthy adults were clone MRI DWI;(2)MR imaging characteristics of 12 patients were observed on the corpus callosum and the other gray-white matters;(3)The ADC values of the central part and marginal area of the corpus callosum and the other gray-white matters were measured,data analysis were carried out completely by random design.Results Hyperintensity on the corpus callosum were showed in 12 patients on DWI,typical“sandwich sign”was seen on the sagittal T2 WI in 1 1 cases,and gray-white matters beside the corpus callosum were involved other in 6 cases;The ADC values of central and marginal area of the corpus callosum and the other gray-white matters had significant differ-ence between the improved clinical symptom group and,unimproved clinical symptom group and the control group (P < 0.05 ). There were no significant differences in the ADC values for the other white matters.Conclusion DWI can be used to reflect the change of MBD.Low ADC values in the corpus callosum and cortex are associated with a poor prognosis.