CAJ | 학술논문

目的：报道1例T细胞前淋巴细胞白血病（T-PLL ）转变为间变性淋巴瘤激酶（ALK）阴性的间变性大细胞淋巴瘤（ALCL，ALK-），并进行文献复习。方法采用MIC 标准诊断。形态学检查包括骨髓涂片（瑞特染色法）、胸水涂片，细胞块、淋巴结活检、免疫化学染色；R显带技术进行细胞遗传学分析；多色流式细胞仪分析免疫表型。结果该患者以 T-PLL 起病，骨髓中异常细胞表型：CD2＋、CD3＋、cCD3＋、CD4＋、CD7＋、CD8-、CD10-、HLA-DR＋、cTDT-、TCRα/β＋，CD38、CD5部分阳性。染色体核型：46，XX。6个月后确诊为ALCL，染色体核型：94，XXX，-X，1q-x2，＋3mar。结论 T-PLL可转变为ALCL，ALK-。
목적：보도1례T세포전림파세포백혈병（T-PLL ）전변위간변성림파류격매（ALK）음성적간변성대세포림파류（ALCL，ALK-），병진행문헌복습。방법채용MIC 표준진단。형태학검사포괄골수도편（서특염색법）、흉수도편，세포괴、림파결활검、면역화학염색；R현대기술진행세포유전학분석；다색류식세포의분석면역표형。결과해환자이 T-PLL 기병，골수중이상세포표형：CD2＋、CD3＋、cCD3＋、CD4＋、CD7＋、CD8-、CD10-、HLA-DR＋、cTDT-、TCRα/β＋，CD38、CD5부분양성。염색체핵형：46，XX。6개월후학진위ALCL，염색체핵형：94，XXX，-X，1q-x2，＋3mar。결론 T-PLL가전변위ALCL，ALK-。
Objective To report a case of T cell prolymphocytic leukemia (T-PLL)transforming to anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL,ALK-),and to review the literatures. Methods The MIC criteria was adopted.Morphology included bone marrow smear (wright staining),pleural effusion smear and cell block,lymph node biopsy,cell chemical dyeing.R banding technique was used in cell genetics analysis, and the immuno-phenotype was analyzed by multicolor flow cytometry.Results The patient was onset as T-PLL,and the abnormal phenotypes in the bone marrow were CD2 +,CD3 +,cCD3 +,CD4 +,CD7 +,CD8 -,CD10 -,HLA-DR+,cTDT-,TCRα/β+ and CD38,CD5 partly positive.Karyotype analysis showed 46,XX.After 6 months, abnormal phenotypes had been changed into ALCL,and karyotype analysis showed 94,XXX,-X,1q-x2,+3mar. Conclusions T-PLL can transform into ALCL,ALK-.