检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2014年
8期
809-812
,共4页
同型半胱氨酸%脂蛋白(a)%高敏C反应蛋白%颈动脉内膜中层厚度
同型半胱氨痠%脂蛋白(a)%高敏C反應蛋白%頸動脈內膜中層厚度
동형반광안산%지단백(a)%고민C반응단백%경동맥내막중층후도
Homocysteine%Lipoprotein(a)%High-sensitivity C-reactive protein%Carotid intima-media thickness
目的:探讨同型半胱氨酸(Hcy)、脂蛋白(a)[Lp(a)]、高敏C反应蛋白(hs-CRP)与颈动脉内膜中层厚度(CIMT)的关系。方法将177名健康体检者根据Hcy测定结果分为高Hcy组(108名)和Hcy正常组(69名),分别测定2组Lp(a)、hs-CRP水平及CIMT,比较高Hcy组和Hcy正常组之间Lp(a)、hs-CRP及CIMT的差异;分析Hcy、Lp(a)、hs-CRP及CIMT之间的相关性。采用受试者工作特征(ROC)曲线分析Hcy、Lp(a)、hs-CRP诊断颈动脉内-中膜增厚的价值。结果高Hcy组hs-CRP及CIMT明显高于Hcy正常组(P=0.000),而Lp(a)两组之间无明显差异(P=0.217)。Hcy、hs-CRP与CIMT呈明显正相关(r值分别为0.660、0.624,P=0.000);Lp(a)与CIMT无相关性(r=0.122,P=0.316);Hcy与hs-CRP呈正相关(r=0.597,P=0.000);Lp(a)与Hcy、hs-CRP无相关性(r值分别为0.063、0.01,P值分别为0.65、0.994)。如以CIMT≥1.00 mm为颈动脉内-中膜增厚,Hcy和hs-CRP的ROC曲线下面积(AUC)分别为0.869(P=0.000)、0.872(P=0.000),而Lp(a)的AUC为0.512(P=0.857)。结论 Hcy、hs-CRP与CIMT明显相关,Hcy和hs-CRP可能在颈动脉内-中膜增厚过程中起重要作用。
目的:探討同型半胱氨痠(Hcy)、脂蛋白(a)[Lp(a)]、高敏C反應蛋白(hs-CRP)與頸動脈內膜中層厚度(CIMT)的關繫。方法將177名健康體檢者根據Hcy測定結果分為高Hcy組(108名)和Hcy正常組(69名),分彆測定2組Lp(a)、hs-CRP水平及CIMT,比較高Hcy組和Hcy正常組之間Lp(a)、hs-CRP及CIMT的差異;分析Hcy、Lp(a)、hs-CRP及CIMT之間的相關性。採用受試者工作特徵(ROC)麯線分析Hcy、Lp(a)、hs-CRP診斷頸動脈內-中膜增厚的價值。結果高Hcy組hs-CRP及CIMT明顯高于Hcy正常組(P=0.000),而Lp(a)兩組之間無明顯差異(P=0.217)。Hcy、hs-CRP與CIMT呈明顯正相關(r值分彆為0.660、0.624,P=0.000);Lp(a)與CIMT無相關性(r=0.122,P=0.316);Hcy與hs-CRP呈正相關(r=0.597,P=0.000);Lp(a)與Hcy、hs-CRP無相關性(r值分彆為0.063、0.01,P值分彆為0.65、0.994)。如以CIMT≥1.00 mm為頸動脈內-中膜增厚,Hcy和hs-CRP的ROC麯線下麵積(AUC)分彆為0.869(P=0.000)、0.872(P=0.000),而Lp(a)的AUC為0.512(P=0.857)。結論 Hcy、hs-CRP與CIMT明顯相關,Hcy和hs-CRP可能在頸動脈內-中膜增厚過程中起重要作用。
목적:탐토동형반광안산(Hcy)、지단백(a)[Lp(a)]、고민C반응단백(hs-CRP)여경동맥내막중층후도(CIMT)적관계。방법장177명건강체검자근거Hcy측정결과분위고Hcy조(108명)화Hcy정상조(69명),분별측정2조Lp(a)、hs-CRP수평급CIMT,비교고Hcy조화Hcy정상조지간Lp(a)、hs-CRP급CIMT적차이;분석Hcy、Lp(a)、hs-CRP급CIMT지간적상관성。채용수시자공작특정(ROC)곡선분석Hcy、Lp(a)、hs-CRP진단경동맥내-중막증후적개치。결과고Hcy조hs-CRP급CIMT명현고우Hcy정상조(P=0.000),이Lp(a)량조지간무명현차이(P=0.217)。Hcy、hs-CRP여CIMT정명현정상관(r치분별위0.660、0.624,P=0.000);Lp(a)여CIMT무상관성(r=0.122,P=0.316);Hcy여hs-CRP정정상관(r=0.597,P=0.000);Lp(a)여Hcy、hs-CRP무상관성(r치분별위0.063、0.01,P치분별위0.65、0.994)。여이CIMT≥1.00 mm위경동맥내-중막증후,Hcy화hs-CRP적ROC곡선하면적(AUC)분별위0.869(P=0.000)、0.872(P=0.000),이Lp(a)적AUC위0.512(P=0.857)。결론 Hcy、hs-CRP여CIMT명현상관,Hcy화hs-CRP가능재경동맥내-중막증후과정중기중요작용。
Objective To investigate the correlation of carotid intima-media thickness(CIMT)with homocysteine (Hcy),lipoprotein(a)[Lp(a)]and high-sensitivity C-reactive protein(hs-CRP).Methods A total of 177 healthy subjects were enrolled and classified into high Hcy group (108 subjects)and normal Hcy group(69 subjects)based on Hcy level.Their Lp(a),hs-CRP and CIMT were determined.The differences of Lp(a),hs-CRP and CIMT between the 2 groups were analyzed comparatively.The correlationship of CIMT with Hcy,Lp(a)and hs-CRP was analyzed. The significance of Hcy,Lp (a)and hs-CRP in the diagnosis of carotid artery intima-media thickness incrassation was evaluated by receiver operating characteristic (ROC)curve.Results The serum levels of hs-CRP and CIMT in high Hcy group were significantly higher than those in normal Hcy group(P=0.000),however there was no significant difference for serum level of Lp(a)between the 2 groups (P=0.217).There was a positive correlation of CIMT with Hcy and hs-CRP (r=0.660 and 0.624,P=0.000).There was no correlation between Lp(a)and CIMT(r=0.122, P=0.316).There was a positive correlation between Hcy and hs-CRP(r =0.597,P =0.000).There was no correlation of Lp(a)with Hcy and hs-CRP(r=0.063,P=0.65;r=0.01,P=0.994).As CIMT ≥1.0 mm as the carotid artery intima-media thickness incrassation upper limit,the areas under ROC curves(AUC)of Hcy,hs-CRP and Lp(a)were 0.869 (P=0.000),0.872 (P=0.000)and 0.512 (P=0.857).Conclusions The correlation of CIMT with Hcy and hs-CRP is significant,and Hcy and hs-CRP play important roles for carotid artery intima-media thickness incrassation.