CAJ | 학술논문

目的：观察沙利度胺对颈动脉粥样硬化患者血清炎性因子及颈动脉粥样斑块的影响。方法将80例颈动脉粥样硬化患者随机分为2组，对照组40例予阿司匹林肠溶片治疗，治疗组40例在对照组治疗基础上加沙利度胺片。2组均3个月为1疗程，2个疗程后检测血清炎性因子肿瘤坏死因子α（ TNF-α）、白细胞介素6（IL-6）、超敏C反应蛋白（hs-CRP）水平及颈动脉IMI、斑块变化情况。结果治疗组治疗后血清TNF-α、IL-6、hs-CRP水平及IMT、斑块积分均较本组治疗前明显降低（P＜0．05），且低于对照组治疗后（P＜0．05），且治疗组治疗后不稳定性斑块减少，稳定性斑块增加，而对照组未见明显变化。结论颈动脉粥样硬化患者采用沙利度胺治疗，能有效降低炎性因子水平，在一定程度改善颈动脉粥样硬化。
목적：관찰사리도알대경동맥죽양경화환자혈청염성인자급경동맥죽양반괴적영향。방법장80례경동맥죽양경화환자수궤분위2조，대조조40례여아사필림장용편치료，치료조40례재대조조치료기출상가사리도알편。2조균3개월위1료정，2개료정후검측혈청염성인자종류배사인자α（ TNF-α）、백세포개소6（IL-6）、초민C반응단백（hs-CRP）수평급경동맥IMI、반괴변화정황。결과치료조치료후혈청TNF-α、IL-6、hs-CRP수평급IMT、반괴적분균교본조치료전명현강저（P＜0．05），차저우대조조치료후（P＜0．05），차치료조치료후불은정성반괴감소，은정성반괴증가，이대조조미견명현변화。결론경동맥죽양경화환자채용사리도알치료，능유효강저염성인자수평，재일정정도개선경동맥죽양경화。
Objective To investigate the effect of thalidomide on the inflammatory factors and carotid artery plaquesinpatientswithcarotidarteryatherosclerosis.Methods 80patientsdiagnosedbyColorDopplerultrasound with carotid artery plaques and abnormal intima -media thickness ( IMT) were randomly divided into treatment group and control group,with each group 40 cases.The treatment group was given Thalidomide 50 mg/d, both of the two groups were given enteric-coated Aspirin 75 mg/d with a lifestyle intervention at the same time .The serum level of tumor necrosis factor -α(TNF-α), inter leukin-6(IL-6), high-sensitive C-reactive Protein (hs-CRP) and the carotid artery IMT , the plaque score and plaque changes were observed before and after treatment of six months . Results Compared with control group and with those before the treatment , the level of TNF-α, IL-6, hs-CRP in treatment group was decreased obviously after six months of treatment ( P <0.05),which situation can also be found in the carotid IMT and the plaque score ( P <0.05),and 29% of unstable plaques changed into stable plaques .Conclusion Thalidomide on patients with carotid atherosclerosis can effectively decrease their inflammato -ry factors and therefore ameliorate carotid artery atherosclerosis .