CAJ | 학술논문

目的：观察当归四逆汤加味联合疏血通注射液治疗2型糖尿病下肢动脉硬化闭塞症的临床疗效。方法将96例2型糖尿病下肢动脉硬化闭塞症患者随机分为2组，治疗组49例除糖尿病基础治疗外给予当归四逆汤加味联合疏血通注射液治疗，对照组47例除糖尿病基础治疗外给予前列地尔注射液治疗。治疗3周后比较2组患者临床疗效及治疗前后的踝肱指数（ABI）、凝血酶原时间（PT）、纤维蛋白原（FIB）、甘油三酯（TG）、总胆固醇（TC）。结果治疗组总有效率95．9％，对照组80．9％，2组比较差异有统计学意义（P＜0．05）。2组治疗后ABI、PT、FIB、TG、TC等指标均改善，治疗组治疗前后比较差异有统计学意义（P＜0．05），治疗组治疗后PT、FIB、TG、TC与对照组比较差异有统计学意义（P＜0．05），治疗组疗效优于对照组。结论当归四逆汤加味联合疏血通注射液治疗2型糖尿病下肢动脉硬化闭塞症及改善糖尿病患者远期疗效确切，值得临床推广应用。
목적：관찰당귀사역탕가미연합소혈통주사액치료2형당뇨병하지동맥경화폐새증적림상료효。방법장96례2형당뇨병하지동맥경화폐새증환자수궤분위2조，치료조49례제당뇨병기출치료외급여당귀사역탕가미연합소혈통주사액치료，대조조47례제당뇨병기출치료외급여전렬지이주사액치료。치료3주후비교2조환자림상료효급치료전후적과굉지수（ABI）、응혈매원시간（PT）、섬유단백원（FIB）、감유삼지（TG）、총담고순（TC）。결과치료조총유효솔95．9％，대조조80．9％，2조비교차이유통계학의의（P＜0．05）。2조치료후ABI、PT、FIB、TG、TC등지표균개선，치료조치료전후비교차이유통계학의의（P＜0．05），치료조치료후PT、FIB、TG、TC여대조조비교차이유통계학의의（P＜0．05），치료조료효우우대조조。결론당귀사역탕가미연합소혈통주사액치료2형당뇨병하지동맥경화폐새증급개선당뇨병환자원기료효학절，치득림상추엄응용。
Objective To observe the effect of Danggui Sini decoction combined with Shuxuetong injection onthetreatmentoftype2diabeticlowerlimbarteriosclerosisobliterans.Methods 96casesoftype2diabeticlower limb arteriosclerosis obliterans were randomly divided into treatment group and control group .The treatment group re-ceived Danggui Sini decoction combined with Shuxuetong injection on the base treatment of diabetes mellitus .Control group used Alprostadil Injection treatment on the base treatment of diabetes mellitus .After three weeks of treatment ABI, PT, FIB, TC and TG were compared in two groups .Results The treatment group could obviously relieve the clinical symptoms.On the overall curative effect of treatment group (95.9%) was better than that of the control group(80.9%, P<0.05).At the same time, compared with the control group could obviously improve the patients with high blood lipid and blood coagulation state .In the aspect of improving ABI was equal to that of the control effect (P<0.05).Conclusion Danggui Sini decoction combined with Shuxuetong injection on the treatment of Type 2 di-abetic lower limb arteriosclerosis obliterans from the aspects of whole regulation and the forward curative effect , treat-ment effect was more ideal .It was worth of clinical promotion .