CAJ | 학술논문

目的：观察参芪地黄汤加减治疗2型糖尿病合并膜性肾病临床疗效。方法将60例2型糖尿病合并膜性肾病患者随机分为2组。对照组30例予西医常规治疗，治疗组30例在对照组治疗基础上加用参芪地黄汤加减治疗。2组均3个月为1个疗程，1个疗程后统计疗效，并观察2组治疗前后中医证候积分、24 h尿蛋白定量（24Upro）、血清白蛋白（Alb）、血清肌酐（Cr）、糖化血红蛋白（HbAlc）及总胆固醇（TC）。结果2组中医、西医总有效率比较差异均有统计学意义（P＜0．05），治疗组疗效优于对照组。2组治疗后中医证候积分、24Upro均降低（P＜0．05），且治疗组降低优于对照组（P＜0．05）；2组治疗后Alb均升高（P＜0．05），且治疗组升高优于对照组（P＜0．05）。2组治疗后Cr、HbAlc及TC与本组治疗前及组间比较差异无统计学意义（P＞0．05）。结论参芪地黄汤加减治疗2型糖尿病合并膜性肾病疗效确切。
목적：관찰삼기지황탕가감치료2형당뇨병합병막성신병림상료효。방법장60례2형당뇨병합병막성신병환자수궤분위2조。대조조30례여서의상규치료，치료조30례재대조조치료기출상가용삼기지황탕가감치료。2조균3개월위1개료정，1개료정후통계료효，병관찰2조치료전후중의증후적분、24 h뇨단백정량（24Upro）、혈청백단백（Alb）、혈청기항（Cr）、당화혈홍단백（HbAlc）급총담고순（TC）。결과2조중의、서의총유효솔비교차이균유통계학의의（P＜0．05），치료조료효우우대조조。2조치료후중의증후적분、24Upro균강저（P＜0．05），차치료조강저우우대조조（P＜0．05）；2조치료후Alb균승고（P＜0．05），차치료조승고우우대조조（P＜0．05）。2조치료후Cr、HbAlc급TC여본조치료전급조간비교차이무통계학의의（P＞0．05）。결론삼기지황탕가감치료2형당뇨병합병막성신병료효학절。
Objective To investigate the clinical effect of Shenqi Dihuang decoction on the treatment of type 2diabeteswithmembranousnephropathy.Methods 60casesoftype2diabeteswithmembranousnephropathywere randomly divided into two groups .Patients in control group ( n=30 ) were treated by western conventional treatment . Patients in treatment group ( n=30 ) were treated by Shenqi Dihuang decoction on the basis of control group treat -ment.The course was three months in two groups .The therapeutic effect was evaluated after a course .TCM score,24 Upro,Alb,Cr,HbAlc and TC in serum were observed before and after treatment in two groups .Results There was significant difference between western medicine and traditional Chinese medicine on the total effective rate in two groups (P<0.05).The therapeutic effect in treatment group was superior to that in control group .TCM score and 24 Upro after treatment were decreased in two groups (P<0.05).The decrease in treatment group was superior to that in control group (P<0.05).Alb after treatment were increased in two groups (P<0.05).The increase in treatment group was superior to that in control group (P<0.05).There was no significant difference between before and after treatment on Cr,HbAlc and Alb in two groups (P>0.05).Conclusion Shenqi Dihuang decoction has definite effect on the treatment of type 2 diabetes with membranous nephropathy .