中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2014年
13期
70-71,72
,共3页
甲氨蝶呤%强的松%类风湿关节炎%护理
甲氨蝶呤%彊的鬆%類風濕關節炎%護理
갑안접령%강적송%류풍습관절염%호리
methotrexate%prednisone%rheumatoid arthritis%nursing
目的：观察甲氨蝶呤联合强的松治疗类风湿关节炎( RA )的效果和并发症，并探讨护理策略。方法选取2012年1月至2013年10月收治的RA患者100例，随机分为观察组和对照组，各50例。对照组应用甲氨蝶呤治疗，观察组应用甲氨蝶呤联合强的松治疗。观察两组患者的疗效，治疗后平均红细胞沉降率（ESR）、C蛋白反应（CRP）、类风湿因子（RF），平均晨僵、握力及不良反应。结果观察组显效率为44.00%，明显高于对照组的34.00%( P﹤0.05)；观察组无效率为4.00%，明显低于对照组的12.00%( P﹤0.05)；观察组治疗后晨僵（2.21±0.08）h，明显低于对照组的（2.57±0.10）h ( P﹤0.05)；观察组治疗后握力为（12.85±0.41）kPa，高于对照组的（10.69±0.58）kPa ( P﹤0.05)；观察组治疗后平均ESR，CRP，RF滴度分别为（24.36±0.93）mm/h，（11.22±0.48）mg/L，11.53±0.40，均明显低于对照组治疗后的（28.71±1.48）mm/h，（13.15±0.50）mg/L，14.07±0.68( P﹤0.05)。两组主要不良反应发生率比较，无统计学差异。结论甲氨蝶呤联合强的松治疗RA疗效显著，患者的症状和主要指标均有明显改善，合理的护理措施亦有助于患者病情的缓解。
目的：觀察甲氨蝶呤聯閤彊的鬆治療類風濕關節炎( RA )的效果和併髮癥，併探討護理策略。方法選取2012年1月至2013年10月收治的RA患者100例，隨機分為觀察組和對照組，各50例。對照組應用甲氨蝶呤治療，觀察組應用甲氨蝶呤聯閤彊的鬆治療。觀察兩組患者的療效，治療後平均紅細胞沉降率（ESR）、C蛋白反應（CRP）、類風濕因子（RF），平均晨僵、握力及不良反應。結果觀察組顯效率為44.00%，明顯高于對照組的34.00%( P﹤0.05)；觀察組無效率為4.00%，明顯低于對照組的12.00%( P﹤0.05)；觀察組治療後晨僵（2.21±0.08）h，明顯低于對照組的（2.57±0.10）h ( P﹤0.05)；觀察組治療後握力為（12.85±0.41）kPa，高于對照組的（10.69±0.58）kPa ( P﹤0.05)；觀察組治療後平均ESR，CRP，RF滴度分彆為（24.36±0.93）mm/h，（11.22±0.48）mg/L，11.53±0.40，均明顯低于對照組治療後的（28.71±1.48）mm/h，（13.15±0.50）mg/L，14.07±0.68( P﹤0.05)。兩組主要不良反應髮生率比較，無統計學差異。結論甲氨蝶呤聯閤彊的鬆治療RA療效顯著，患者的癥狀和主要指標均有明顯改善，閤理的護理措施亦有助于患者病情的緩解。
목적：관찰갑안접령연합강적송치료류풍습관절염( RA )적효과화병발증，병탐토호리책략。방법선취2012년1월지2013년10월수치적RA환자100례，수궤분위관찰조화대조조，각50례。대조조응용갑안접령치료，관찰조응용갑안접령연합강적송치료。관찰량조환자적료효，치료후평균홍세포침강솔（ESR）、C단백반응（CRP）、류풍습인자（RF），평균신강、악력급불량반응。결과관찰조현효솔위44.00%，명현고우대조조적34.00%( P﹤0.05)；관찰조무효솔위4.00%，명현저우대조조적12.00%( P﹤0.05)；관찰조치료후신강（2.21±0.08）h，명현저우대조조적（2.57±0.10）h ( P﹤0.05)；관찰조치료후악력위（12.85±0.41）kPa，고우대조조적（10.69±0.58）kPa ( P﹤0.05)；관찰조치료후평균ESR，CRP，RF적도분별위（24.36±0.93）mm/h，（11.22±0.48）mg/L，11.53±0.40，균명현저우대조조치료후적（28.71±1.48）mm/h，（13.15±0.50）mg/L，14.07±0.68( P﹤0.05)。량조주요불량반응발생솔비교，무통계학차이。결론갑안접령연합강적송치료RA료효현저，환자적증상화주요지표균유명현개선，합리적호리조시역유조우환자병정적완해。
Objective To observe the effect and complications of methotrexate combined with prednisone in treating rheumatoid arthritis ( RA ) and to discuss the nursing strategy. Methods 100 cases of RA treated in our hospital from January 2012 to October 2013 were selected and randomly divided into the observation group and the control group, 50 cases in each group. The control group used the methotrexate therapy, while the observation group adopted the therapy of methotrexate combined with prednisone. The curative effects after treatment, average ESR, CRP, RF, average morning stiffness, griping power and adverse reactions were observed in the two groups. Results The significantly effective rate of the observation group was 44. 00%, which was higher than 34. 00% in the contorl group ( P﹤0. 05 );the ineffective rate of the observation group was 4. 00%, which was lower than 12. 00% of the control group ( P﹤0. 05 );the morning stiff-ness after treatment in the observation group was ( 2. 21 ± 0. 08 ) h, which was lower than ( 2. 57 ± 0. 10 ) h in the control group ( P﹤0. 05 );the gripping power of the observation group was ( 12. 85 ± 0. 41 ) kPa, which was higher than ( 10. 69 ± 0. 58 ) kPa of the control group ( P﹤0. 05 );the average ESR, CRP and RF of the observation group were ( 24. 36 ± 0. 93 ) mm/h, ( 11. 22 ± 0. 48 ) mg/L and 11. 53 ± 0. 40 respectively, which were lower than ( 28. 71 ± 1. 48 ) mm/h, ( 13. 15 ± 0. 50 ) mg/L and 14. 07 ± 0. 68 of the control group ( P﹤ 0. 05 ) . The major adverse reactions between the two groups had no statistically significant difference. Conclusion Methotrexate combined with pred-nisone for treating RA has significantly clinical effect and obviously improve the patient's symptoms and the main indicators. The ratio-nal nursing under this basis also conduces to alleviate the patient's condition.
