中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2014年
13期
30-31
,共2页
小儿氨酚黄那敏颗粒%马来酸氯苯那敏%高效液相色谱法
小兒氨酚黃那敏顆粒%馬來痠氯苯那敏%高效液相色譜法
소인안분황나민과립%마래산록분나민%고효액상색보법
Xiaoer Anfen Huang Namin Granules%chlorphenamine maleate%high performance liquid chromatography
目的:建立小儿氨酚黄那敏颗粒中马来酸氯苯那敏含量测定的高效液相色谱法。方法色谱柱为Lichrospher C18柱(200 mm ×4.6 mm,5μm),流动相为乙腈0.5%十二烷基硫酸钠溶液-磷酸(60:40:0.1),流速为1.0 mL/min,进样量为20μL,检测波长为210 nm。结果马来酸、氯苯那敏进样质量浓度线性范围为6.37~42.50μg/mL( r=0.9995,n=5),平均回收率为100.18%,RSD=1.19%( n=9)。结论该方法简单、快捷、结果准确、重现性好。
目的:建立小兒氨酚黃那敏顆粒中馬來痠氯苯那敏含量測定的高效液相色譜法。方法色譜柱為Lichrospher C18柱(200 mm ×4.6 mm,5μm),流動相為乙腈0.5%十二烷基硫痠鈉溶液-燐痠(60:40:0.1),流速為1.0 mL/min,進樣量為20μL,檢測波長為210 nm。結果馬來痠、氯苯那敏進樣質量濃度線性範圍為6.37~42.50μg/mL( r=0.9995,n=5),平均迴收率為100.18%,RSD=1.19%( n=9)。結論該方法簡單、快捷、結果準確、重現性好。
목적:건립소인안분황나민과립중마래산록분나민함량측정적고효액상색보법。방법색보주위Lichrospher C18주(200 mm ×4.6 mm,5μm),류동상위을정0.5%십이완기류산납용액-린산(60:40:0.1),류속위1.0 mL/min,진양량위20μL,검측파장위210 nm。결과마래산、록분나민진양질량농도선성범위위6.37~42.50μg/mL( r=0.9995,n=5),평균회수솔위100.18%,RSD=1.19%( n=9)。결론해방법간단、쾌첩、결과준학、중현성호。
Objective To develop a high performance liquid chromatography ( HPLC ) method for the content determination of chlorpheni-ramine maleate in Xiaoer Anfen Huang Namin Granules. Methods The Lichrospher C18 column ( 200 mm × 4. 6 mm, 5μm ) was adopted;the mobile phase was acetonitrile-0. 5% sodiuam lauryl sulfate-phosphoric acid ( 60 : 40 : 0. 1 ); the flow rate was 1. 0 mL/min;the injection volume was 20 μL; the detection wavelengh was 210 nm. Results The linear range of chlorpheniramine maleate was 6. 37-42. 50 μg/mL ( r=0. 999 5, n=5 ) , the average recovery rate was 100. 18%, RSD=1. 19% ( n=9). Conclusion This method is simple, rapid, accurate and repeatable.