CAJ | 학술논문

肿瘤是严重危害人类健康的常见的重大疾病，机体对细胞的生长和分裂失去控制，细胞的增殖与凋亡调节失衡是肿瘤发生主要因素之一。细胞失控性异常增殖是肿瘤最突出的生物学特性。生存素（Survivin）作为近年来被发现的凋亡抑制蛋白（IAP）家族中的新成员，研究表明其细胞凋亡抑制效应最强，组织学表达具备肿瘤高度特异性，在抑制肿瘤细胞凋亡方面发挥重要作用。本文就 Survivin 的分子结构、生物学性能、与肿瘤发生发展的关系及其在肿瘤基因治疗中的作用作一综述。
종류시엄중위해인류건강적상견적중대질병，궤체대세포적생장화분렬실거공제，세포적증식여조망조절실형시종류발생주요인소지일。세포실공성이상증식시종류최돌출적생물학특성。생존소（Survivin）작위근년래피발현적조망억제단백（IAP）가족중적신성원，연구표명기세포조망억제효응최강，조직학표체구비종류고도특이성，재억제종류세포조망방면발휘중요작용。본문취 Survivin 적분자결구、생물학성능、여종류발생발전적관계급기재종류기인치료중적작용작일종술。
Tumor is a commonly major disease which seriously threatens human health and the growth of cells divides is out of control. The imbalance of cell proliferation and apoptosis is one of the important factors. The abnormal proliferation of tumor cells is the most prominent biological characteristic. Survivin, an inhibitor of apoptosis (IAP) family member protein which inhibits apoptosis and drives cell proliferation, is commonly elevated in human cancer, play an important role in inhibiting tumor cell apoptosis. In this paper, the molecular structure of survivin, biological properties, with the development of the relationship between tumor and its role in tumor gene therapy were reviewed.