中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
15期
2833-2836
,共4页
胰高血糖素样肽1%心血管系统%体重%糖尿病,2型
胰高血糖素樣肽1%心血管繫統%體重%糖尿病,2型
이고혈당소양태1%심혈관계통%체중%당뇨병,2형
Glucagon-like peptide 1%Cardiovascular system%Body weight%Diabetes mellitus,type 2
胰高血糖素样肽-1（GLP-1）属于肠降血糖素激素家族：由远端消化道（回肠和结肠）L细胞（一种内分泌细胞）分泌，以葡萄糖依赖的模式促进胰岛素释放及抑制胰高糖素分泌，从而降低血糖。近年来越来越多的临床证据显示，GLP-1拥有更广泛而重要的胰腺外作用，如通过抑制食欲、延缓胃排空作用使体重减轻，改善内皮细胞功能、心脏功能，抗炎、降脂对心血管起到保护作用。本文就胰高血糖素样肽-1及其受体激动剂对体重减轻和心血管系统影响作一综述。
胰高血糖素樣肽-1（GLP-1）屬于腸降血糖素激素傢族：由遠耑消化道（迴腸和結腸）L細胞（一種內分泌細胞）分泌，以葡萄糖依賴的模式促進胰島素釋放及抑製胰高糖素分泌，從而降低血糖。近年來越來越多的臨床證據顯示，GLP-1擁有更廣汎而重要的胰腺外作用，如通過抑製食欲、延緩胃排空作用使體重減輕，改善內皮細胞功能、心髒功能，抗炎、降脂對心血管起到保護作用。本文就胰高血糖素樣肽-1及其受體激動劑對體重減輕和心血管繫統影響作一綜述。
이고혈당소양태-1（GLP-1）속우장강혈당소격소가족：유원단소화도（회장화결장）L세포（일충내분비세포）분비，이포도당의뢰적모식촉진이도소석방급억제이고당소분비，종이강저혈당。근년래월래월다적림상증거현시，GLP-1옹유경엄범이중요적이선외작용，여통과억제식욕、연완위배공작용사체중감경，개선내피세포공능、심장공능，항염、강지대심혈관기도보호작용。본문취이고혈당소양태-1급기수체격동제대체중감경화심혈관계통영향작일종술。
Glucagon-like peptide-1 (GLP-1) belongs to the incretin hormone family:secreted by the distal gastrointestinal tract (the ileum and colon) L cells (a kind of endocrine cells) and reduces blood glucose through the stimulation of insulin secretion and the inhibition of glucagon release. In recent years, more and more clinical evidences dedicate that GLP-1 possesses more extensive and important functions out of pancreas including slowing gastric emptying, reducing food intake, improving endothelial function, cardiac function, anti-inflammatory response, lowering blood pressure, lipid, reducing weight via inhibiting feeding behavior and delaying gastrointestinal motility, thus it can benefit on cardiovascular function. This paper aimed at reviewing the effects of glucagon-like peptide-1 and its receptor agonists on weight loss and the cardiovascular system.
