CAJ | 학술논문

目的：比较枸橼酸钙和碳酸钙治疗骨质疏松症的疗效，并进行药物经济学评价。方法选择2012年12月至2013年12月该院门诊治疗的骨质疏松症患者180例，随机分为A、B两组，每组90例。A组口服枸橼酸钙，B组口服碳酸钙。观察两组疗效和不良反应，并运用成本-效果比（C/E）进行分析。结果枸橼酸钙总有效率为85.56%，碳酸钙总有效率为83.33%，两组比较，差异无统计学意义（P＞0.05）。枸橼酸钙组不良反应发生情况低于碳酸钙组，差异有统计学意义（P<0.05）。两组C/E比较，差异无统计学意义（P＞0.05）。结论枸橼酸钙和碳酸钙治疗骨质疏松症的药物疗效和成本相似，但枸橼酸钙不良反应发生情况更少。
목적：비교구연산개화탄산개치료골질소송증적료효，병진행약물경제학평개。방법선택2012년12월지2013년12월해원문진치료적골질소송증환자180례，수궤분위A、B량조，매조90례。A조구복구연산개，B조구복탄산개。관찰량조료효화불량반응，병운용성본-효과비（C/E）진행분석。결과구연산개총유효솔위85.56%，탄산개총유효솔위83.33%，량조비교，차이무통계학의의（P＞0.05）。구연산개조불량반응발생정황저우탄산개조，차이유통계학의의（P<0.05）。량조C/E비교，차이무통계학의의（P＞0.05）。결론구연산개화탄산개치료골질소송증적약물료효화성본상사，단구연산개불량반응발생정황경소。
Objective To compare the clinical efficacy of calcium citrate and calcium carbonate in treating osteoporosis and to evaluate the pharmacoeconomics. Methods A total of 180 patients with osteoporosis who were treated in the hospital from December 2012 to December 2013 ,were randomly divided into group A and group B ,90 cases in each group. The group A was with oral calcium citrate,while the group B were administrated with calcium carbonate orally. Clinical efficacy and adverse reac-tion in the two groups were observed,and analyzed by cost-effect ratio(C/E). Results The total effective rate was 85.56%of calcium citrate and 83.33%of the calcium carbonate,and the difference between the two groups had no statistical significance(P>0.05). The incidence rate of adverse reaction of calcium citrate was lower than that of calcium carbonate with statistically significant difference(P<0.05). There was no statistically significant difference on E/C between the two groups(P>0.05). Conclusion Calci-um citrate and calcium carbonate have similar efficacy and cost-effec tiveness in the treatment of osteoporosis ,but the incidence rate of adverse reaction of calcium citrate is lower.