CAJ | 학술논문

目的：研究低体温对伏立康唑药代动力学的影响。方法20只家兔随机均分为低体温组和对照组。低体温组采用（21±1）℃海水浸泡60 min致低体温造模。给予2组兔单剂量伏立康唑（10 mg/kg），取血并监测体温，高效液相色谱法测定不同时间点伏立康唑血药浓度，3P97软件计算药代动力学参数。结果低体温组动物体温在浸泡过程中及出水后一段时间持续下降，在36 h后恢复正常（36.6±0.8）℃。伏立康唑在低体温组和对照组兔体内药代动力学发生变化，药物半衰期和清除率差异有统计学意义（P＜0.05），但达峰时间、药物浓度-时间曲线下面积（area under concentration-time curve，AUC0-t）或AUC0-∞差异无统计学意义（P＞0.05）。结论伏立康唑在海水浸泡致低体温家兔体内清除减慢。
목적：연구저체온대복립강서약대동역학적영향。방법20지가토수궤균분위저체온조화대조조。저체온조채용（21±1）℃해수침포60 min치저체온조모。급여2조토단제량복립강서（10 mg/kg），취혈병감측체온，고효액상색보법측정불동시간점복립강서혈약농도，3P97연건계산약대동역학삼수。결과저체온조동물체온재침포과정중급출수후일단시간지속하강，재36 h후회복정상（36.6±0.8）℃。복립강서재저체온조화대조조토체내약대동역학발생변화，약물반쇠기화청제솔차이유통계학의의（P＜0.05），단체봉시간、약물농도-시간곡선하면적（area under concentration-time curve，AUC0-t）혹AUC0-∞차이무통계학의의（P＞0.05）。결론복립강서재해수침포치저체온가토체내청제감만。
Objective To investigate the pharmacokinetic changes of voriconazole ( VOZ) in seawater immersed hypothermic rabbits .Methods Twenty healthy rabbits were randomly assigned to two groups ( n=10 ): hypothermic group and control group .Rabbits in hypothermic group were immersed into (21±1)℃seawater for 60 mins before administration.All the rabbits were adminis-tered a single oral dose of 10 mg/kg VOZ.The temperature and VOZ in plasma of the rabbits at different sampling time were determined .Pharmacokinetic parameters were calculated by 3P97 soft-ware .Results The temperature of hypothermic rabbits were declined during and after the seawater immersion, and back to normal at 36 h after immersion (36.6±0.8)℃.Pharmacokinetic of vorico-nazole was changed .Compared with rabbits in control group , half-life time ( t1/2 ) and ( clearances ) CLs of hypothermia rabbits were significantly reduced (P<0.05), but tmax, area under concentra-tion-time curve (AUC0-t), and AUC0-∞ had no significant difference (P>0.05).Conclusion Clearance of voriconazole in seawater immersed hypothermia rabbits slowed down .