CAJ | 학술논문

Yes相关蛋白（ Yes-associated protein ，YAP ）是Hippo信号通路最主要的调控因子，具有促进细胞增殖、抑制细胞凋亡的作用。在人类乳腺癌、肺癌、结直肠癌、胃癌、卵巢癌等多种肿瘤中YAP表达明显上调。而在另一方面，当DNA损伤时，作为转录辅助激活因子的YAP增强p73相关凋亡基因的转录，具有促进凋亡作用。在细胞内环境的维持与调控过程中，YAP 所发挥的作用截然不同。本文主要介绍Hippo信号通路、YAP、p73在恶性肿瘤中的作用，以及YAP与p73在肿瘤细胞中的具体调控机制和作用。
Yes상관단백（ Yes-associated protein ，YAP ）시Hippo신호통로최주요적조공인자，구유촉진세포증식、억제세포조망적작용。재인류유선암、폐암、결직장암、위암、란소암등다충종류중YAP표체명현상조。이재령일방면，당DNA손상시，작위전록보조격활인자적YAP증강p73상관조망기인적전록，구유촉진조망작용。재세포내배경적유지여조공과정중，YAP 소발휘적작용절연불동。본문주요개소Hippo신호통로、YAP、p73재악성종류중적작용，이급YAP여p73재종류세포중적구체조공궤제화작용。
Yes-associated protein ( YAP ) is a major regulator of Hippo signal pathway , which can promote cell proliferation and inhibit apoptosis .YAP expressed in many malignant tumor , such as breast cancer , lung cancer , colon cancer , stomach cancer and ovarian cancer , and it was significantly up-regulated .On the other hand , as a transcriptional co-activator ,YAP enhanced tran-scription of p73 to promote the cell apoptosis when DNA damaged .The process of preserve and regu-lating the intracellular environment , YAP bring into the different play .In this review , we will briefly discuss the action of Hippo pathway , YAP and p73 in malignant tumors , the specific regulatory mechanisms and the function of YAP and p 73 in tumor development .