中国药物应用与监测
中國藥物應用與鑑測
중국약물응용여감측
CHINESE JOURNAL OF DRUG APPLICATION AND MONITORING
2014年
4期
255-256
,共2页
乙酰半胱氨酸%QT间期延长%药品不良反应
乙酰半胱氨痠%QT間期延長%藥品不良反應
을선반광안산%QT간기연장%약품불량반응
Acetylcysteine%QT interval prolongation%Adverse drug reaction
1例68岁女性患者,因肺间质纤维化口服乙酰半胱氨酸片0.6 g,tid。用药第3天患者诉心前区疼痛、心慌、胸闷。心电图示短阵房性心动过速、ST-T改变、QT间期延长,QTc 503 ms。心梗三项、电解质、BNP均在正常范围内。遂停用乙酰半胱氨酸片,其余治疗继续,停药第2天患者未再出现心慌等不适症状,复查QTc 446 ms。停药第3天患者病情好转出院。
1例68歲女性患者,因肺間質纖維化口服乙酰半胱氨痠片0.6 g,tid。用藥第3天患者訴心前區疼痛、心慌、胸悶。心電圖示短陣房性心動過速、ST-T改變、QT間期延長,QTc 503 ms。心梗三項、電解質、BNP均在正常範圍內。遂停用乙酰半胱氨痠片,其餘治療繼續,停藥第2天患者未再齣現心慌等不適癥狀,複查QTc 446 ms。停藥第3天患者病情好轉齣院。
1례68세녀성환자,인폐간질섬유화구복을선반광안산편0.6 g,tid。용약제3천환자소심전구동통、심황、흉민。심전도시단진방성심동과속、ST-T개변、QT간기연장,QTc 503 ms。심경삼항、전해질、BNP균재정상범위내。수정용을선반광안산편,기여치료계속,정약제2천환자미재출현심황등불괄증상,복사QTc 446 ms。정약제3천환자병정호전출원。
One 68-year-old female patient was administrated with acetylcysteine tablets (0.6 g, tid) due to the pulmonary fibrosis. Three days later, the patient complained of chest pain, palpitation and chest tightness. Electrocardiogram showed that paroxysmal atrial tachycardia and ST-T change;the QT interval prolonged and the value of QTc was 503 ms, while the three factors of myocardial infarction, electrolytes and BNP were within the normal range. Then acetylcysteine tablets were stopped immediately, but other medications continued. The next day the patient's uncomfortable symptoms disappeared, and the value of QTc dropped to 446 ms. The patient was discharged with improved condition on the third day after drug withdrawal.