中国药物应用与监测
中國藥物應用與鑑測
중국약물응용여감측
CHINESE JOURNAL OF DRUG APPLICATION AND MONITORING
2014年
4期
253-254
,共2页
替加环素%肾功能不全%肌酐升高%药品不良反应
替加環素%腎功能不全%肌酐升高%藥品不良反應
체가배소%신공능불전%기항승고%약품불량반응
Tigecycline%Renal insufifciency%Elevated creatinine%Adverse drug reaction
1例90岁男性患者因社区获得性肺炎住院，痰培养结果提示鲍曼不动杆菌，尿培养结果提示粪肠球菌。因患者有严重慢性肾功能不全病史，结合药敏结果选用替加环素进行抗感染治疗，初始剂量100 mg，之后给予维持剂量50 mg，q 12 h， ivgtt。用药3 d后，患者出现肌酐水平显著升高，立即停药。停药后肌酐水平呈进行性下降趋势，4 d恢复到用药前水平。
1例90歲男性患者因社區穫得性肺炎住院，痰培養結果提示鮑曼不動桿菌，尿培養結果提示糞腸毬菌。因患者有嚴重慢性腎功能不全病史，結閤藥敏結果選用替加環素進行抗感染治療，初始劑量100 mg，之後給予維持劑量50 mg，q 12 h， ivgtt。用藥3 d後，患者齣現肌酐水平顯著升高，立即停藥。停藥後肌酐水平呈進行性下降趨勢，4 d恢複到用藥前水平。
1례90세남성환자인사구획득성폐염주원，담배양결과제시포만불동간균，뇨배양결과제시분장구균。인환자유엄중만성신공능불전병사，결합약민결과선용체가배소진행항감염치료，초시제량100 mg，지후급여유지제량50 mg，q 12 h， ivgtt。용약3 d후，환자출현기항수평현저승고，립즉정약。정약후기항수평정진행성하강추세，4 d회복도용약전수평。
One 90-year-old male patient with severe chronic renal insufifciency hospitalized due to community acquired pneumonia. Combining with sputum culture, urine culture and antibiotic sensitivity selection, tigecycline was used with initial dose of 100 mg, then followed by 50 mg every 12 hours. Three days later, creatinine signiifcantly increased, and decreased after withdrawal of tigecycline. Four days later, creatinine returned to the level of pretreatment.
