CAJ | 학술논문

目的：对通心络胶囊治疗急性脑梗死的临床效果进行评价，为临床应用提供循证医学证据。方法：全面检索通心络胶囊治疗急性脑梗死的临床研究文献，并按照文献选择标准进行筛选，对符合纳入标准的文献进行质量评价。采用RevMan 5.0软件对以基础治疗为对照组，在基础治疗上加用通心络胶囊治疗作为治疗组的随机对照试验进行Meta分析。结果：共纳入13篇文献，通心络组治疗急性脑梗死的疗效高于对照组，无明显不良反应。合并RR =1.26，95％CI [1.20，1.33]。结论：通心络治疗急性脑梗死的疗效优于对照组，但由于本研究存在一定的不足，对其疗效及安全性仍有待大样本、多中心、随机对照试验加以验证。
목적：대통심락효낭치료급성뇌경사적림상효과진행평개，위림상응용제공순증의학증거。방법：전면검색통심락효낭치료급성뇌경사적림상연구문헌，병안조문헌선택표준진행사선，대부합납입표준적문헌진행질량평개。채용RevMan 5.0연건대이기출치료위대조조，재기출치료상가용통심락효낭치료작위치료조적수궤대조시험진행Meta분석。결과：공납입13편문헌，통심락조치료급성뇌경사적료효고우대조조，무명현불량반응。합병RR =1.26，95％CI [1.20，1.33]。결론：통심락치료급성뇌경사적료효우우대조조，단유우본연구존재일정적불족，대기료효급안전성잉유대대양본、다중심、수궤대조시험가이험증。
Objective: To assess the effectiveness of Tongxinluo capsules in the treatment of acute cerebral infarction by Meta-analysis. Methods:The clinical studies of Tongxinluo capsules in treating acute cerebral infarction were collected and selected according to the criteria. Randomized controlled trials with the control group using basic treatment, while the treatment group using basic treatment combined with Tongxinluo capsules were included in this Meta-analysis. Results: A total of 13 RCTs were included. Tongxinluo treatment group showed better effectiveness than the control group. Adverse drug reactions and other harmful consequences weren't reported. The combined risk ratio (RR) was 1.26, 95%CI was [1.20, 1.33]. Conclusion:Our results showed Tongxinluo group was superior to control group in treating acute cerebral infarction. However, existence of some data methodological defects maybe directly affect the authenticity of the results. High quality, large samples and multiple center randomized controlled trials were needed to conifrm the efifcacy and safety.