CAJ | 학술논문

目的：研究甘草祛风汤治疗慢性特发性荨麻疹（CIU）的临床疗效及其对血清IFN-γ和IL-4水平的影响。方法将60例CIU患者随机分为两组，分别予甘草祛风汤和盐酸西替利嗪片进行治疗，观察疗效和复发率。采用ELISA法测定IFN-γ和IL-4水平，并与40例健康对照组进行比较。结果甘草祛风汤组经治疗后第4周，第12周疗效评价均优于西替利嗪组，治疗后第12周复发率两组相比差异有统计学意义（ P＜0.01）。 CIU患者血清IFN-γ和IL-4水平与健康对照组差异有统计学意义（ P＜0.01），甘草祛风汤组经治疗后第4周、第12周血清IFN-γ和IL-4水平与治疗前及西替利嗪组相比均有统计学意义（ P均＜0.01）。结论甘草祛风汤可有效治疗CIU，且疗效持久，复发率较低。通过检测并比较两种反映Th1/Th2平衡的细胞因子水平，发现甘草祛风汤可有效提高血清IFN-γ水平，降低IL-4水平，对恢复机体自身免疫平衡有积极的作用。
목적：연구감초거풍탕치료만성특발성담마진（CIU）적림상료효급기대혈청IFN-γ화IL-4수평적영향。방법장60례CIU환자수궤분위량조，분별여감초거풍탕화염산서체리진편진행치료，관찰료효화복발솔。채용ELISA법측정IFN-γ화IL-4수평，병여40례건강대조조진행비교。결과감초거풍탕조경치료후제4주，제12주료효평개균우우서체리진조，치료후제12주복발솔량조상비차이유통계학의의（ P＜0.01）。 CIU환자혈청IFN-γ화IL-4수평여건강대조조차이유통계학의의（ P＜0.01），감초거풍탕조경치료후제4주、제12주혈청IFN-γ화IL-4수평여치료전급서체리진조상비균유통계학의의（ P균＜0.01）。결론감초거풍탕가유효치료CIU，차료효지구，복발솔교저。통과검측병비교량충반영Th1/Th2평형적세포인자수평，발현감초거풍탕가유효제고혈청IFN-γ수평，강저IL-4수평，대회복궤체자신면역평형유적겁적작용。
Objective To investigate the effect of gancaoqufeng tang on the serum IFN-γand IL-4 of patients with chronic idiopathic urticaria (CIU).Methods 60 patients with CIU were divided into two groups randomly.The patients in experimental group were treated with gancaoqiefeng tang and the control group was treated with cetirizine hydrochloride tablets.The clinical effect and recurrence rate were observed and the serum IFN-γand IL-4 were test-ed by ELISA method.Results The recurrence rate of experimental group were significant lower than control grroup after 12 weeks ( P=0 .001 ) .Compare with control group , the serum level of IFN-γincreased and the level of ser-um IL-4 decreased in experimental group ( P=0.001 ) .Conclusion Gancaoqufeng tang caneffectively decrease the recurrence rate of chronic idiopathic urticaria .It would effectively increase the level of serum IFN-γand reduce the level of serum IL-4 , which indicates that it have a positive effect to restore the body's immune balance .