CAJ | 학술논문

目的：研究联合使用吸入性糖皮质激素及短效β2受体兴奋剂治疗慢性阻塞性肺疾病（ COPD）并糖尿病大鼠，对大鼠血糖的变化以及死亡率的影响。方法：选取80只造模成功的COPD并糖尿病大鼠，随机分为A组、B组、C组、D组，每组各20只，分别给予单独吸入糖皮质激素治疗、单独吸入短效β2受体兴奋剂治疗、联合吸入糖皮质激素及短效β2受体兴奋剂治疗、生理盐水对照。各组大鼠雾化吸入治疗15 min/次，2次/d，疗程均为10 d。结果：联合吸入糖皮质激素及短效β2受体兴奋剂治疗的血糖控制情况与其他组比较无显著性差异（ P ＞0.05），但联合吸入治疗组死亡率较其他组低（ P ＜0.05）。结论：联合吸入糖皮质激素及短效β2受体兴奋剂治疗对COPD并糖尿病大鼠的血糖控制无影响，而且可以提高治疗水平，改善预后，降低死亡率。
목적：연구연합사용흡입성당피질격소급단효β2수체흥강제치료만성조새성폐질병（ COPD）병당뇨병대서，대대서혈당적변화이급사망솔적영향。방법：선취80지조모성공적COPD병당뇨병대서，수궤분위A조、B조、C조、D조，매조각20지，분별급여단독흡입당피질격소치료、단독흡입단효β2수체흥강제치료、연합흡입당피질격소급단효β2수체흥강제치료、생리염수대조。각조대서무화흡입치료15 min/차，2차/d，료정균위10 d。결과：연합흡입당피질격소급단효β2수체흥강제치료적혈당공제정황여기타조비교무현저성차이（ P ＞0.05），단연합흡입치료조사망솔교기타조저（ P ＜0.05）。결론：연합흡입당피질격소급단효β2수체흥강제치료대COPD병당뇨병대서적혈당공제무영향，이차가이제고치료수평，개선예후，강저사망솔。
Objective:To study the glucose changes and mortality in diabetic rats with COPD of inhaling corticosteroids and short -acting β2 agonist .Methods:80 successful modeling diabetic rats with COPD were randomly divided into four groups of A ,B,C,D,n=20 in each group;there were the inhaled corticosteroids group, the inhaled short -acting β2 agonist group, the united inhaled glucocorticoids and short -acting β2 agonists group ,the saline control group;the atomization inhalation therapy in each group was for 15 minutes/time, 2 times/day;All groups were treated for 10 days.Results:The blood glucose control situation was no significant difference ( P>0.05 ) between the united glucocorticoid and short -actingβ2 receptor agonist group and other groups , but the the mortality in united inhalation group was lower than in -other groups ( P <0.05 ) .Conclusion:The United inhaled glucocorticoids and short -acting β2 agonist in treatment of diabetes with COPD have no effect on blood sugar control , and can more effectively enhance therapeutic levels , improve their prognosis and reduce mortality .