CAJ | 학술논문

目的：从血浆细胞因子水平和疼痛分级关系研究比较开胸与胸腔镜手术（ VATS）对患者的创伤影响。方法28例T1N0M0患者被随机分配至VATS（10例，4例退出）或开胸组（14例）行肺叶切除及淋巴结清扫术，在术后0，1，2，7，14天对术后疼痛进行分级，并在相对应的术后时间同时采集血液标本检测血浆细胞因子白介素-6（ IL-6）水平。结果术后0，1，7，14天的疼痛分级VATS组明显低于开胸组，血浆IL-6水平在开胸组中术后0天为（11.91±5.247） pg/mL，与VATS组（7.375±5.3） pg/mL比较明显升高，P＝0.0177。结论 VATS与开胸术比较，可减少血浆细胞因子IL-6的释放，减轻手术引起的疼痛。
목적：종혈장세포인자수평화동통분급관계연구비교개흉여흉강경수술（ VATS）대환자적창상영향。방법28례T1N0M0환자피수궤분배지VATS（10례，4례퇴출）혹개흉조（14례）행폐협절제급림파결청소술，재술후0，1，2，7，14천대술후동통진행분급，병재상대응적술후시간동시채집혈액표본검측혈장세포인자백개소-6（ IL-6）수평。결과술후0，1，7，14천적동통분급VATS조명현저우개흉조，혈장IL-6수평재개흉조중술후0천위（11.91±5.247） pg/mL，여VATS조（7.375±5.3） pg/mL비교명현승고，P＝0.0177。결론 VATS여개흉술비교，가감소혈장세포인자IL-6적석방，감경수술인기적동통。
Objective To evaluatie the injury caused by video-assisted thoracic surgery ( VATS) and open thoractomy by measuring the level of IL-6 and postoperative pain grade . Methods Twenty-eight patients whom underwent the lobectomy and lymph nodes dissection were randomized into VATS group ( 10 cases ) and open thoractomy group ( 14 cases ) .The postoperative pain was evaluated at the time of postoperative day of 0, 1, 2, 4, 7, 14, the blood samples were collected at the same time interval , and the level of IL-6 was measured . Results The pain scale was higher in open group than that in VATS , the level of IL-6 was in-creased at 0 day more in open which was (11.91 ±5.247 ) pg/mL than (7.375 ±5.3 ) pg/mL in VATS, P =0.0177.Conclusion VATS can decrease release of IL-6, and relieve the pain.