CAJ | 학술논문

Napsin A是一种天门冬氨酸蛋白酶,主要表达于肺和肾脏的上皮细胞中.研究发现,在肺部肿瘤中,Napsin A主要在肺腺癌中表达.在肾脏肿瘤中,Napsin A主要表达在肾细胞癌,尤其是乳头样和透明样肾细胞癌.鉴于此,Napsin A在肺腺癌和肾细胞癌的诊断及鉴别诊断中起到重要作用.本文就近年来关于Napsin A在肿瘤中作用的研究进展作一综述.
Napsin A시일충천문동안산단백매,주요표체우폐화신장적상피세포중.연구발현,재폐부종류중,Napsin A주요재폐선암중표체.재신장종류중,Napsin A주요표체재신세포암,우기시유두양화투명양신세포암.감우차,Napsin A재폐선암화신세포암적진단급감별진단중기도중요작용.본문취근년래관우Napsin A재종류중작용적연구진전작일종술.
Napsin A is one kind of aspartic protease present in the epithelial cells of the lung and kidney.Recent studies have shown that,in lung tumors,napsin A expression is restricted to lung adenocarcinomas,whereas among renal tumors,it is mainly expressed in renal cell carcinomas,especially the papillary and clear cell subtypes.In view of its restricted expression,napsin A plays an important role in the diagnosis and differential diagnosis of both lung adenocarcinoma and renal cell carcinoma.In the current review,we summarize the most recent data on napsin A and its relationship with cancer.